Heterocycle substituted amino-pyridine compounds and methods of use thereof

A compound of Formula (III) or a pharmaceutically acceptable salt thereof:

• wherein
• ring A is 5-membered heteroaryl or 5-membered heterocycloalkyl;
• R1 is hydroxyl, C1-C6 alkoxyl, or mono- or di-C1-C6-alkylamino and said C1-C6 alkoxyl, or mono- or di-C1-C6-alkylamino is optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C1-C6 alkoxyl, C6-C10 aryloxy, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, oxo, C6-C10 aryl or 5- or 6-membered heteroaryl;
• R2 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C1-C6 alkoxyl, C6-C10 aryloxy, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, oxo, C6-C10 aryl or 5- or 6-membered heteroaryl and R2 is optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, C(O)OH, C(O)O—C1-C6 alkyl, cyano, C1-C6 alkyl, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 12-membered heterocycloalkyl, and 5- or 6-membered heteroaryl, wherein when ring A is pyrazolyl, R2 is attached to the pyrazolyl via a carbon ring atom thereof;
• R3 is H, halo, cyano, azido, oxo, ORa, —NRaRb, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —NRbC(O)Ra, —S(O)bRa, —S(O)bNRaRb, or RS0, in which RS0 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C10 aryl, C6-C10 aryloxy, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, 4 to 12-membered heterocycloalkyl, or 5- or 6-membered heteroaryl, b is 0, 1, or 2, each of Ra and Rb, independently is H or RS1, and RS1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 12-membered heterocycloalkyl, or 5- or 6-membered heteroaryl;
• or Ra and Rb, together with the N atom to which they are attached, form a 4 to 12-membered heterocycloalkyl ring having 0 or 1 additional heteroatom;
• and each of RS0, RS1, and the 4 to 12-membered heterocycloalkyl ring formed by Ra and Rb, is optionally substituted with one or more -Q1-T1, wherein Q1 is a bond, C(O), a C1-C6 alkyl linker, or a 4- to 6-membered heterocycloalkyl linker and T1 is selected from the group consisting of halo, hydroxyl, oxo, C(O)OH, C(O)O—C1-C6 alkyl, cyano, C1-C6 alkyl, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 12-membered heterocycloalkyl, and 5- or 6-membered heteroaryl, wherein when T1 is C1-C6 alkyl, C1-C6 alkoxyl,C(O)O—C1-C6 alkyl, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 12-membered heterocycloalkyl, or 5- or 6-membered heteroaryl, T1 is optionally substituted with one or more substituents selected from the group consisting of halo, C1-C4 alkyl, and C6-C10 aryl;
• and
• R4 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C1-C6 alkoxyl, C6-C10 aryloxy, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, oxo, C6-C10 aryl or 5- or 6-membered heteroaryl and when R4 is not H, R4 is optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, C(O)OH, C(O)O—C1-C6 alkyl, cyano, C1-C6 alkyl, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 12-membered heterocycloalkyl, and 5- or 6-membered heteroaryl, wherein when ring A is pyrazolyl, R4 is attached to the pyrazolyl via a carbon ring atom thereof, and when neither R2 nor R4 is H, only one of R2, R3, and R4 is aryl or heteroaryl.