Back to results
US 2017/0291889 A1Published application
Pyrazole derivatives as sgc stimulators
AssigneeIronwood Pharmaceuticals, Inc.
InventorsTimothy Claude BARDEN, James Edward SHEPPECK, Glen Robert RENNIE, Paul Allan RENHOWE, Nicholas PERL, Takashi NAKAI, Ara MERMERIAN, Thomas Wai-Ho LEE, Joon JUNG, James JIA, Karthik IYER, Rajesh R. IYENGAR, G-Yoon Jamie IM
Life of this patent
Estimating the term…
Abstract
Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
Claims24
A compound selected from those depicted in Table IA or Table IB or a pharmaceutically acceptable salt thereof:
- TABLE IA
- 6
- 8
- 9
- 10
- 19
- 21
- 22
- 24
- 29
- 37
- 61
- 109
- 110
- 111
- 142
- 143
- 144
- 145
- 146
- 182
- 185
- 186
- 187
- 188
- 189
- 190
- 191
- 192
- 205
- 207
- 197
- 208
- 213
- 212
- 211
- 214
- 216
- 215
- 209
- TABLE IB
- 1
- 3
- 4
- 5
- 7
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 20
- 25
- 26
- 27
- 28
- 30
- 32
- 33
- 34
- 35
- 36
- 38
- 39
- 40
- 41
- 42
- 43
- 44
- 45
- 46
- 47
- 48
- 49
- 50
- 51
- 52
- 54
- 55
- 56
- 57
- 59
- 60
- 62
- 64
- 65
- 66
- 67
- 68
- 69
- 70
- 71
- 72
- 73
- 74
- 75
- 76
- 77
- 78
- 79
- 80
- 81
- 82
- 83
- 84
- 85
- 86
- 87
- 88
- 89
- 90
- 91
- 92
- 93
- 94
- 95
- 96
- 97
- 98
- 99
- 102
- 103
- 105
- 106
- 107
- 108
- 112
- 113
- 114
- 115
- 116
- 117
- 118
- 119
- 120
- 121
- 122
- 123
- 124
- 125
- 126
- 127
- 128
- 129
- 130
- 131
- 132
- 133
- 134
- 135
- 136
- 137
- 138
- 139
- 140
- 141
- 147
- 148
- 149
- 150
- 151
- 152
- 153
- 154
- 155
- 156
- 157
- 158
- 159
- 160
- 161
- 162
- 163
- 164
- 165
- 166
- 167
- 168
- 169
- 170
- 171
- 172
- 173
- 174
- 175
- 176
- 177
- 178
- 179
- 180
- 181
- 183
- 184
- 193
- 194
- 195
- 196
- 198
- 199
- 200
- 201
- 202
- 203
- 204
- 206
- 217
205 more elements
(canceled)
(canceled)
20-25. (canceled)
28-37. (canceled)
Dependencies are inferred from the claim text.