Solid Forms of Mirabegron
AssigneeApotex Inc.
InventorsAllan W. Rey, Annyt Bhattacharyya, Jenny L. Gerster, Sammy Chris Duncan, Mohammed Abdul Raheem, Fan Wang, Stuart P. Green
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Abstract
Solid forms of Mirabegron, including forms APO-I, APO-II, and various salt forms, and processes for the preparation thereof, are provided.
Claims17
Form APO-I of Mirabegron wherein a Powder X-Ray Diffraction (PXRD) diffractogram comprising a peak, in terms of degrees 2θ, at 7.4+/−0.2, in addition to at least three peaks, in terms of degrees 2θ, selected from the group consisting of:
- 8.9+/−0.2, 16.3+/−0.2, 16.8+/−0.2, 19.8+/−0.2, 21.2+/−0.2, 24.3+/−0.2, and 25.6+/−0.2.
(canceled)
Form APO-II of Mirabegron wherein a Powder X-Ray Diffraction (PXRD) diffractogram comprising peaks, in terms of degrees 2θ, at 9.7+/−0.2, 15.5+/−0.2, 17.1+/−0.2, and 18.5+/−0.2 and at least one peak selected from the group consisting of:
- 12.3+/−0.2 and 13.8+/−0.2.
A process for the preparation of form APO-I of Mirabegron comprising treating a mixture of Mirabegron in a solvent comprising (S)-(+)-1,2-propanediol with an antisolvent to provide form APO-I of Mirabegron.
(canceled)
(canceled)
-30. (canceled)
Dependencies are inferred from the claim text.