Cancer Cell Growth Inhibitor, Anticancer Agent, and Method for Screening Same, as well as Novel Compound
AssigneesMicrobial Chemistry Research Foundation, Gakubunkan
InventorsSonoko Atsumi, Masabumi Shibuya, Shun-ichi Ohba, Tomoyuki Kimura, Yoshihiko Kobayashi, Hayamitsu Adachi, Chisato Nosaka, Akio Nomoto
Life of this patent
Estimating the term…
Abstract
A cancer cell proliferation inhibitor including at least one selected from compounds represented by Structural Formulae (1) to (8), wherein the cancer cell is at least one of a cancer cell overexpressing a wild-type epidermal growth factor receptor and a cancer cell expressing an epidermal growth factor receptor mutant vIII.
Claims11
A cancer cell proliferation inhibitor comprising
- a compound represented by Structural Formula (8) below,
- wherein the cancer cell is at least one of a cancer cell overexpressing a wild-type epidermal growth factor receptor and a cancer cell expressing an epidermal growth factor receptor mutant vIII:
(canceled)
An anti-cancer agent comprising
- a cancer cell proliferation inhibitor comprising:
- a compound represented by Structural Formula (8) below,
- wherein the cancer cell proliferation inhibitor inhibits proliferation of at least one of a cancer cell overexpressing a wild-type epidermal growth factor receptor and a cancer cell expressing an epidermal growth factor receptor mutant vIII:
A method for screening at least one of a cancer cell proliferation inhibitor and an anti-cancer agent, the method comprising:
- culturing a NIH3T3 cell expressing an epidermal growth factor receptor mutant vIII in a medium including a test substance under an environment without an adhesion scaffold;
- culturing a NIH3T3 cell in a medium including the test substance under an environment with an adhesion scaffold;
- and
- evaluating the test substance as having an activity as at least one of the cancer cell proliferation inhibitor and the anti-cancer agent when the test substance does not inhibit proliferation of the NIH3T3 cell, but inhibits proliferation of the NIH3T3 cell expressing an epidermal growth factor receptor mutant vIII.
A compound represented by Structural Formula (8) below:
A compound-including composition comprising
A method for inhibiting proliferation of a cancer cell, the method comprising:
- using at least one selected from compounds represented by Structural Formulae (1) to (8) below,
- wherein the cancer cell is at least one of a cancer cell overexpressing a wild-type epidermal growth factor receptor and a cancer cell expressing a wild-type epidermal growth factor receptor and a cancer cell expressing an epidermal growth factor receptor mutant vIII:
A method for preventing or treating cancer, the method comprising:
- administering, to an individual, an anti-cancer agent comprising at least one selected from compounds represented by Structural Formulae (1) to (8) below:
Dependencies are inferred from the claim text.