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US 2017/0291878 A1Published application
Method for producing optically active valeric acid derivative
AssigneeDaiichi Sankyo Company, Limited
InventorsTsuyoshi UEDA, Kazutoshi UKAI
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Abstract
A method for producing a compound (3), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific chiral ligand and a ruthenium catalyst, or in the presence of an asymmetric transition metal complex catalyst previously generated from the chiral ligand and the ruthenium catalyst.
Claims11
A method of producing a compound of formula (3):
- comprising allowing a compound of formula (1):
- to react with hydrogen gas, in an inert solvent, in the presence of a chiral ligand of formula (2):
- and a ruthenium catalyst, or in the presence of an asymmetric transition metal complex catalyst previously generated from the chiral ligand and the ruthenium catalyst,
- wherein P1 and P2 are each independently a hydrogen atom or a protective group for the amino group,
- R1 is an (S)-ethyl-di-2-methylphenylphosphino group or an (S)-α-N,N-dimethylaminophenylmethyl group,
- R2 is a di-tert-butylphosphino group, a di(3,5-dimethyl-4-methoxyphenyl)-phosphino group, or a di(3,5-dimethylphenyl)-phosphino group,
- R3 is an (S)-α-N,N-dimethylaminophenylmethyl group or a hydrogen atom, and
- R4 is a di(3,5-dimethyl-4-methoxyphenyl)-phosphino group, a di(3,5-dimethylphenyl)-phosphino group, or a hydrogen atom.
5 more elements
Dependencies are inferred from the claim text.