Quinolones as inhibitors of class iv bromodomain proteins

A compound of general formula I:

• wherein:
• R3 is selected from —R3A and —OR3B wherein R3A and R3B are each independently selected from hydrogen, C1-4alkyl and C1-4haloalkyl;
• R4 is selected from —R4A and —OR4B wherein R4A and R4B are each independently selected from hydrogen, C1-4alkyl and C1-4haloalkyl;
• R5 is selected from —R5A and —OR5B wherein R5A is independently selected from hydrogen, halo, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C3-6cycloalkyl and C1-4haloalkyl, and wherein R5B is independently selected from hydrogen, C1-4alkyl, C3-6cycloalkyl and C1-4haloalkyl;
• R7 is selected from —R7A and —OR7B wherein R7A and R7B are each independently selected from hydrogen, C1-4alkyl, C3-6cycloalkyl, and C1-4haloalkyl;
• R8 is selected from —R8A and —OR8B wherein R8A is independently selected from hydrogen, halo, C1-4alkyl, and C1-4haloalkyl, and wherein R8B is independently selected from hydrogen, C1-4alkyl and C1-4haloalkyl;
• RN is selected from C1-4alkyl, C1-4haloalkyl, RZ, and —ZN—RZ wherein ZN is C1-4alkylene and each RZ is independently C3-6cycloalkyl;
• L is a sulfonamide linker;
• X is selected from aryl, C1-6alkyl and C3-6cycloalkyl and is optionally substituted.