Use of transcranial magnetic stimulation to modulate permeability of the blood-brain barrier
AssigneeBrainsway, Ltd.
InventorsGABY PELL, ABRAHAM ZANGEN, YIFTACH ROTH, ALON FRIEDMAN, UDI VAZANA
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Abstract
Transcranial magnetic stimulation (TMS) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep TMS coil may be placed on a head in a vicinity of a tumor, for example. A series of magnetic pulses is provided to the brain with a tailored stimulation protocol. In one of many possible clinical applications, a pharmaceutical substance may be introduced during a time frame before, during or after providing the magnetic pulses to treat a tumor in the brain.
Claims20
A method for modulating permeability of a blood brain barrier, the method comprising:
- providing a system for transcranial magnetic stimulation;
- placing said system on a scalp;
- and
- providing a series of magnetic pulses to a brain via the system, said providing done in a range of at least 0.2 Hz stimulation frequency, greater than 120% of resting motor threshold stimulation amplitude, and at least 100 stimulation pulses, wherein said series of magnetic pulses is configured to temporarily increase permeability of the blood brain barrier, wherein the temporary increase is for a period of at least 1 minute.
A system for modulating permeability of the blood brain barrier, the system comprising:
- a transcranial magnetic stimulation coil for transcranial magnetic stimulation and configured to:
- be placed on a scalp;
- and
- provide a series of magnetic pulses in a range of at least 0.2 Hz stimulation frequency, greater than 120% of resting motor threshold stimulation amplitude, and at least 100 stimulation pulses, wherein said series of magnetic pulses is configured to temporarily change permeability of the blood brain barrier for a period of at least 1 minute.
Dependencies are inferred from the claim text.