Medicament Preparation and Treatment Devices, Methods, and Systems

A fluid circuit for preparation of a medicament for renal replacement therapy, comprising:

• a concentrate container containing acid concentrate connected for flow communication, through a first pumping tube segment, to a medicament supply line that has been capped and sterile-sealed at an outlet end thereof;
• a bicarbonate cartridge containing dry bicarbonate buffer compound, the bicarbonate cartridge being of a type that admits water in a cartridge inlet thereby forming a saturated bicarbonate solution which is received at a cartridge outlet, the cartridge outlet being connected for flow communication, through a second pumping tube segment, to the medicament supply line;
• and
• a water inlet line, capped and sterile-sealed, connected for flow communication, through a third pumping tube segment, to the medicament supply line and connected for flow communication to the bicarbonate cartridge inlet;
• the first, second, and third pumping tube segments being supported by a circuit cartridge which orients, aligns, and exposes for access the first, second, and third pumping tube segments with respective actuators of a predefined medicament preparation device;
• the circuit cartridge containing a first concentration sensor station positioned in said medicament supply line downstream of a first junction where a first of said first and second pumping tube segments connects to the medicament supply line;
• the circuit cartridge containing a second concentration sensor station positioned in said medicament supply line downstream of both said first junction and a second junction where a second of said first and second pumping tube segments connects to the medicament supply line;
• the entire fluid circuit being sterile.