Pet solutions and methods of making pet solutions for medical devices
AssigneeCardiac Pacemakers, Inc.
InventorsJoseph T. Delaney, JR., David R. Wulfman, Adeniyi O. Aremu, Adegbola O. Adenusi
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Abstract
A method of making a solution including poly(ethylene terephthalate). The method includes dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including two solvent components. A Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5.
Claims20
A method of making a solution including poly(ethylene terephthalate), the method comprising:
- dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including at least two solvent components, wherein a solubility of the poly(ethylene terephthalate) in the solvent mixture is at least about 2 wt. % at a temperature from about 20° C. to about 25° C., wherein a Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5.
A method for making an implantable medical device including a poly(ethylene terephthalate) layer, the method comprising:
- formulating a poly(ethylene terephthalate) solution by dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including at least two solvent components, wherein a solubility of the poly(ethylene terephthalate) in the solvent mixture is at least about 2 wt. % at a temperature from about 20° C. to about 25° C., wherein a Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5;
- depositing the poly(ethylene terephthalate) solution onto the implantable medical device;
- and
- drying the implantable medical device and evaporating the solvent mixture to leave behind the poly(ethylene terephthalate) layer.
A composition comprising:
- a first solvent;
- a second solvent;
- and
- poly(ethylene terephthalate) in solution with the first solvent and the second solvent in an amount no less than about 2 wt. %,
- wherein a Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5.
Dependencies are inferred from the claim text.