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AssigneeSofradim Production
InventorsRobert Vestberg, Sebastien Ladet, Mylene Desorme, Camille Noorman
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The present invention relates to a method for preparing a chitosan matrix having good mechanical properties comprising the steps of a) preparing a solution of chitosan, b) pouring the solution of a) into a mould in order to form a layer, c) lyophilizing the layer of b) in order to obtain a matrix of chitosan, d) sterilizing the matrix obtained in c) by water vapor treatment. The invention also relates to the matrices obtained and to surgical implants comprising such matrices. The invention further relates to a method for increasing the suture retention strength of a chitosan matrix obtained by lyophilization of a chitosan solution, and to a method for for decreasing the solubilization rate in hydrochloric acid of a chitosan matrix obtained by lyophilization of a chitosan solution, comprising the step of sterilizing said matrix by a water vapor treatment.
1-17. (canceled)
A method for preparing a sterile chitosan matrix having enhanced mechanical properties comprising the steps of:
A surgical implant comprising a chitosan matrix in a sterile form, wherein a suture retention strength of the chitosan matrix in the sterile form is at least 30% greater than the suture retention strength of the chitosan matrix in a non-sterile form.
A surgical implant comprising a chitosan matrix in a first sterile form, the chitosan matrix in the first sterile form having an average suture retention strength at least 41% greater than the average suture retention strength of the chitosan matrix in a second sterile form different from the first sterile form, wherein the chitosan matrix in the second sterile form is sterilized by gamma radiation or ethylene oxide.
Dependencies are inferred from the claim text.