Hydrophilic coatings through in situ surface polymerization
AssigneeCardiac Pacemakers, Inc.
InventorsJohn Kummailil, Paul V. Grosso, Joseph T. Delaney, JR.
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Abstract
A medical device for insertion or implantation in a body includes a polymer substrate and a layer of poly(vinyl pyrrolidone-alt-maleic anhydride) formed on a surface of the polymer substrate. Polymer chains of the poly(vinyl pyrrolidone-alt-maleic anhydride) are entangled with the polymer substrate.
Claims20
A medical device for insertion or implantation in a body, the medical device comprising:
- a polymer substrate;
- and
- a layer of poly(vinyl pyrrolidone-alt-maleic anhydride) formed on a surface of the polymer substrate, wherein polymer chains of the poly(vinyl pyrrolidone-alt-maleic anhydride) are entangled with the polymer substrate to form a lubricious, hydrophilic layer.
A method of forming a lubricious, hydrophilic polymer coating on a surface of a polymer substrate of a medical device, the method comprising:
- depositing a monomer solution onto the surface of the polymer substrate, the monomer solution including maleic anhydride, a hydrophilic olefinic monomer, and an optional swelling agent, wherein at least one of the hydrophilic olefinic monomer and the optional swelling agent swells the polymer substrate;
- and
- polymerizing the maleic anhydride and the hydrophilic olefinic monomer of the monomer solution by radical polymerization to form chains of an alternating copolymer of the maleic anhydride and the hydrophilic olefinic monomer, wherein some of the chains of the alternating copolymer of the maleic anhydride and the hydrophilic olefinic monomer are entangled in the swollen polymer substrate.
A method of forming a lubricious, hydrophilic polymer coating on a surface of a polymer substrate of an implantable or insertable medical device, the method comprising:
- treating the surface of the polymer substrate with a plasma to form free radicals on the surface of the polymer substrate;
- depositing the monomer solution onto the surface of the polymer substrate to covalently bond a portion of the N-vinyl pyrrolidone monomer to the polymer substrate, the monomer solution including maleic anhydride monomer and N-vinyl pyrrolidone monomer, wherein the N-vinyl pyrrolidone swells the polymer substrate;
- and
- polymerizing the maleic anhydride monomer and the N-vinyl pyrrolidone monomer of the monomer solution, wherein the free radicals on the polymer substrate initiate a radical polymerization of the maleic anhydride monomer and the N-vinyl pyrrolidone monomer to form chains of poly(vinyl pyrrolidone-alt-maleic anhydride), wherein some of the chains of the poly(vinyl pyrrolidone-alt-maleic anhydride) are entangled in the swollen polymer substrate to form the lubricious, hydrophilic polymer coating.
Dependencies are inferred from the claim text.