Anticoagulant derivatives for cardiovascular imaging
OwnerDavid R Elmalehinventor
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Abstract
The invention provides cardiovascular imaging agents comprising an anticoagulant (e.g., dabigatran derivatives) with a label (e.g., radiolabeled, fluorinated or radiofluorinated). Methods for using the cardiovascular imaging agents and kits containing the cardiovascular imaging agents or components suitable for production of the cardiovascular imaging agents are also provided.
Claims16
A direct thrombin inhibitor (DTI) derivative comprising the DTI or a product of the DTI with a PET and a SPECT label.
A dabigatran DTI derivative or a product of dabigatran DTI derivative with a PET and SPECT label, represented by structure (A):
- wherein R is H, Et, Me, or Bu;
- R2 is H, Et, Me, Bu;
- n is a number from 2 to 6;
- m is a number from 2 to 6;
- Z is alkyl, substituted alkyl, alkylene, aryl, or halogen;
- Y is alkyl, substituted alkyl, alkylene, aryl, or halogen;
- and
- X is halogen, radiohalogen, chelating moiety or radiolabeled chelating moiety.
A method of treating atherosclerotic plaque or thrombus in a subject, comprising administering to a subject an effective dosage of an unlabeled DTI derivative, whereby the atherosclerotic plaque or thrombus in said subject is treated.
A method of treating atherosclerotic plaque or thrombus in a subject, comprising administering to a subject an effective dosage of an unlabeled dabigatran DTI derivative, whereby the atherosclerotic plaque or thrombus in said subject is treated.
Use of an unlabeled dabigatran DTI derivative for the manufacture of a medicament for the treatment of atherosclerotic plaque or thrombus in a subject.
An unlabeled dabigatran DTI derivative for use in treating atherosclerotic plaque or thrombus in a subject.
Dependencies are inferred from the claim text.