Grp78 targeted conjugates
AssigneeUniversity of Iowa Research Foundation
InventorsSomya Kapoor, Michael K. Schultz
Life of this patent
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Abstract
Accordingly, certain embodiments of the invention provide a conjugate of formula (I): P-(X-D)n, wherein P is a peptide that binds to a glucose regulated protein 78 (GRP78); X is a direct bond or a linking group; D is a detectable agent; and n is 1 to 4. Certain embodiments of the invention provide a pharmaceutical composition comprising a conjugate of formula (I) and a pharmaceutically acceptable excipient. Certain embodiments of the invention provide a method for treating or preventing cancer in an animal (e.g., a human) comprising administering a therapeutically effective amount of a conjugate of formula (I) (e.g., a conjugate comprising a therapeutic radionuclide) to the animal.
Claims34
A conjugate of formula (I):
- P-(X-D)n (I)
- wherein:
- P is a peptide that binds to a glucose regulated protein 78 (GRP78);
- X is a direct bond or a linking group;
- D is a detectable agent;
- and
- n is 1 to 4.
2-4. (canceled)
6-9. (canceled)
12-18. (canceled)
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22-35. (canceled)
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40-42. (canceled)
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A GRP78 targeting peptide comprising amino acid sequence GWAFSIPL (SEQ ID NO:4).
52-55. (canceled)
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60-61. (canceled)
63-64. (canceled)
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Dependencies are inferred from the claim text.