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US 2017/0290928 A1Published application
Use of charge-balanced imaging agents for determining renal function
AssigneesBeth Israel Deaconess Medical Center, Inc., Georgia State University Research Foundation, Inc.
InventorJohn V. Frangioni
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Abstract
The present invention relates to a method for detecting renal disease and for assessing the efficacy of dialysis treatment using imaging agents having desirable in vivo properties.
Claims21
A method of detecting renal disease comprising:
- (a) administering a predetermined dosage of an imaging agent comprising a dye or conjugate thereof, the conjugate comprising a targeting ligand attached to the dye, wherein the dye or conjugate has a net charge of +1, 0, or −1 and comprises one or more ionic groups to a subject;
- (b) obtaining a sample from the subject;
- and
- (c) determining the amount of imaging agent recovered in said sample, wherein an amount of charge-balanced imaging agent recovered in the sample of less than 70% of the predetermined dosage in the sample is indicative of renal disease.
1 more element
A method for determining efficacy of dialysis comprising
- (a) administering a predetermined dosage of an imaging agent comprising a dye or conjugate thereof, the conjugate comprising a targeting ligand attached to the dye, wherein the dye or conjugate has a net charge of +1, 0, or −1 and comprises one or more ionic groups to a subject in need of dialysis treatment prior to administration of dialysis treatment;
- (b) obtaining a pre-treatment sample from the subject;
- (c) determining the amount of imaging agent recovered in said pre-treatment sample;
- (d) administering another predetermined dosage of the imaging agent to a subject in need of dialysis treatment after administration of dialysis treatment;
- (e) obtaining a post-treatment sample from the subject;
- (f) determining the amount of the imaging agent recovered in said post-treatment sample;
- and
- (g) comparing the amount of imaging agent recovered in the pre-treatment sample with the amount of imaging agent recovered in the post-treatment sample, wherein an increase of the amount of imaging agent recovered in the post-treatment indicated an effective dialysis treatment.
5 more elements
Dependencies are inferred from the claim text.