Materials and Methods for the Delivery of a Nanocarrier to the Brain
AssigneeThe Florida International University Board of Trustees
InventorsAjeet KAUSHIK, Madhavan NAIR
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Abstract
Materials and methods for magnetically guided delivery of nanoparticles across the blood brain barrier (BBB) in the central nervous system (CNS) are provided. The method can comprise injecting a subject with an aqueous solution comprising magneto-electro nanoparticles and applying a static magnetic field directed toward the subject brain, thereby inducing a stimulus response of the nanoparticles in a controlled manner. Materials and methods provided herein are effective in delivering the nanoparticles across the BBB in the brains of animal subjects including mice and non-human primate such as baboon.
Claims20
A method of delivering a drug to the brain of a subject, comprising:
- administering to the subject a composition comprising magneto-electro nanocarriers (MENCs) loaded with the drug, and
- applying a static magnetic field directed toward a treatment area of the brain, the strength of the magnetic field being sufficient to deliver the MENCs across a blood brain barrier (BBB) to the treatment area.
A method of treating the brain of a subject, comprising:
- administering a composition comprising magneto-electro nanoparticles (MENCs) loaded with a drug, each MENC having a diameter of less than 50 nm;
- applying a first magnetic field directed toward a treatment area of the brain, the strength of the first magnetic field being sufficient to deliver the MENCs across a blood brain barrier (BBB) to the treatment area;
- and
- applying a second magnetic field directed toward the treatment area of the brain, the strength of the second magnetic field being sufficient to release the drug in a controlled manner,
- the first magnetic field being a static magnetic field and the second magnetic field being an alternating current magnetic field.
A method of treating the brain of a subject, comprising:
- injecting the subject with an aqueous solution comprising magneto-electro nanoparticles (MENCs), the MENCs having a diameter of between 20 nm and 30 nm and comprising CoFe2O4 at the core and BaTiO3 at the surface of each nanoparticle, and the MENCs being loaded with a drug capable of treating a brain disease;
- and
- applying a static magnetic field, having a strength of less than 10 T, directed toward a treatment area of the brain, the strength of the magnetic field being sufficient to deliver the MENCs across the blood brain barrier (BBB) to the treatment area.
Dependencies are inferred from the claim text.