Viral vectors and their use in therapeutic methods
AssigneesThe General Hospital Corporation, Georgetown University, Catherex, Inc.
InventorsPaul Johnson, Robert L. Martuza, Samuel D. Rabkin, Tomoki Todo
Life of this patent
Estimating the term…
Abstract
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
Claims23
-5. (canceled)
A method of inducing a systemic immune response to cancer in a patient, said method comprising administering to said patient a herpes simplex virus-1 (HSV-1) comprising an inactivating mutation in the ICP47 locus of said herpes virus that results in early expression of US11, and (ii) an inactivating mutation in the γ34.5 neurovirulence locus of said virus.
(canceled)
-23. (canceled)
-30. (canceled)
A method of treating a head and neck squamous cell carcinoma, hepatoma, or breast cancer in a patient, said method comprising administering to said patient a herpes simplex virus-1 (HSV-1) comprising (i) an inactivating mutation in the ICP47 locus of said herpes virus that results in early expression of US11, and (ii) an inactivating mutation in the γ34.5 neurovirulence locus of said virus.
Dependencies are inferred from the claim text.