Biochemically stabilized hiv-1 env trimer vaccine
AssigneesBeth Israel Deaconess Medical Center, Inc., Children's Medical Center Corporation
InventorsStephen C. HARRISON, Bing CHEN, Dan H. BAROUCH, Joseph P. NKOLOA, Michael Scott SEAMAN
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Abstract
Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
Claims21
1-20. (canceled)
An isolated nucleic acid molecule encoding at least one gp140 polypeptide, wherein said gp140 polypeptide comprises an amino acid sequence at least 98% identical to residues 30-708 of SEQ ID NO:2, wherein said gp140 polypeptide further comprises an oligomerization domain.
An isolated nucleic acid molecule encoding at least one gp140 polypeptide, wherein said gp140 polypeptide comprises an amino acid sequence is at least 98% identical to SEQ ID NO:2, wherein said gp140 polypeptide further comprises an oligomerization domain.
Dependencies are inferred from the claim text.