VLPS Containing Ligands and Methods Related Thereto
AssigneesEmory University, Children's Healthcare of Atlanta, Inc.
InventorsRichard Compans, Baozhong Wang, Fu Shi Quan, Martin Moore
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Abstract
This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a TLR5 agonist on the exterior without an antigen.
Claims3
An immunogenic composition comprising a virus-like carrier having influenza virus matrix protein wherein influenza virus matrix protein is M1 and a RSV protein is G protein or glycoprotein on the surface in the absence of the F protein or glycoprotein.
An RSV-G virus-like particle produced by infecting insect cells with rBVs encoding RSV-G and influenza M1 and not the RSV-F gene.
A method of vaccinating a subject comprising administering an immunogenic composition comprising a virus-like carrier having influenza virus matrix protein wherein influenza virus matrix protein is M1 and a RSV protein is G protein or glycoprotein on the surface in the absence of the F protein or glycoprotein.
Dependencies are inferred from the claim text.