Methods and compositions for treating dysbiosis and gastrointestinal and inflammatory disorders
AssigneeNew York University
InventorsP'ng Loke, Kenneth Cadwell, Deepshika Ramanan, Rowann Bowcutt
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Abstract
The present invention relates to the use of type 2 cytokines and mucins for increasing the amount or activity of bacterial species of the Clostridia class in the gastrointestinal tract, for treating dysbiosis in the gastrointestinal tract, for treating gastrointestinal and inflammatory disorders, and for promoting wound healing in the gastrointestinal tract.
Claims20
A method for increasing the amount or activity of one or more bacterial species of the Clostridia class in the gastrointestinal tract of a subject comprising administering to said subject a therapeutically effective amount of at least one type 2 cytokine and/or at least one mucin.
A method for treating dysbiosis in the gastrointestinal tract of a subject in need thereof, wherein the dysbiosis is associated with a decrease in the amount or activity of one or more bacterial species of the Clostridia class in the gastrointestinal tract of the subject, said method comprising administering to said subject a therapeutically effective amount of at least one type 2 cytokine and/or at least one mucin.
A method for treating a gastrointestinal or inflammatory disorder in a subject in need thereof, which disorder can be treated by increasing the amount or activity of one or more bacterial species of the Clostridia class in the gastrointestinal tract of the subject, said method comprising administering to said subject a therapeutically effective amount of at least one type 2 cytokine and/or at least one mucin.
A method for promoting a wound healing in the gastrointestinal tract of a subject in need thereof comprising administering to said subject a therapeutically effective amount of the at least one type 2 cytokine and/or the at least one mucin.
A composition comprising two or more components selected from the group consisting of (i) at least one type 2 cytokine, (ii) at least one mucin, (iii) bacteria of the Clostridia class, (iv) bacteria, yeast or virus expressing a type 2 cytokine, (v) yeast or virus expressing a mucin, and (vi) a helminth.
Dependencies are inferred from the claim text.