Oral spray containing ixeris dentata nakai extract as active ingredient for preventing or treating xerostomia caused by diabetes

Abstract

An oral spray formulation using an Ixeris dentata Nakai extract as an active ingredient of a composition for preventing and treating xerostomia occurring as a diabetic complication, particularly an oral spray formulation capable of administering a drug through a simple and rapidly absorbable route is provided. The secretion of saliva is reduced as cells from a submandibular gland tissue of a diabetes model animal are destroyed. However, when the Ixeris dentata Nakai extract of the present invention is sublingually sprayed into a sublingual region of the diabetes model animal, expression levels of α-amylase, AQP5 and NHE1 can significantly increase, resulting in an increased secretion quantity and rate of saliva. When the Ixeris dentata Nakai extract is administered using the formulation of the present invention, the Ixeris dentata Nakai extract is sublingually sprayed through the spray formulation, and thus can be directly locally administered to a salivary gland tissue having an activity to induce secretion of saliva. Therefore, saliva secretion can be induced by rapid absorption of the active ingredient of the Ixeris dentata Nakai extract in the salivary gland tissue without any absorption process through the digestive system, resulting in minimized side effects.

Dependencies are inferred from the claim text.