Treatment of diabetic foot ulcer using placental stem cells
AssigneeAnthrogenesis Corporation
InventorsSteven A. FISCHKOFF, Denesh CHITKARA, Uri HERZBERG, Vladimir JANKOVIC
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Abstract
Provided herein are methods of using tissue culture plastic-adherent placental cells, e.g. placental stem cells, in the treatment of diabetic foot ulcer (DFU).
Claims19
A method of treating a subject having a diabetic foot ulcer, comprising administering to the subject a composition comprising CD10+, CD34−, CD105+, CD200+ placental stem cells.
A method for treating DFU in a subject in need of treatment, comprising (a) determining the number of endothelial cells circulating in the bloodstream of the subject;
- (b) administering a composition comprising CD10+, CD34−, CD105+, CD200+ placental stem cells to the subject;
- and (c) determining the number of endothelial cells circulating in the bloodstream of the subject following administration of the placental stem cells, wherein a decrease in the number of circulating endothelial cells following administration of placental stem cells as compared to the number of circulating endothelial cells before administration of placental stem cells indicates that treatment of DFU in said subject is effective.
A method for treating DFU in a subject in need of treatment, comprising:
- (a) administering a composition comprising CD10+, CD34−, CD105+, CD200+ placental stem cells to the subject;
- (b) determining the number of endothelial cells circulating in the bloodstream of the subject at a first time point following administration of the placental stem cells;
- and (c) determining the number of endothelial cells circulating in the bloodstream of the subject at a second time point following administration of the placental stem cells, wherein a decrease in the number of circulating endothelial cells measured at the second time point as compared to the number of circulating endothelial cells measured at the first time indicates that treatment of DFU in said subject is effective.
Dependencies are inferred from the claim text.