Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
AssigneeCedars-Sinai Medical Center
InventorsEduardo Marban, Mark Amin Aminzadeh
Life of this patent
Estimating the term…
Abstract
Described herein are compositions and techniques related to generation and therapeutic application of cardiosphere-derived cells (CDCs) and CDC-derived exosomes. These cells and their secreted vesicles contain a unique milieu of biological factors, including cytokines, growth factors, transcription factors, nucleic acids including non-coding nucleic acids such as microRNAs, that serve to initiate and promote many therapeutic effects. Exosomes and their “cargo” contents, such as microRNAs can favorably modulate apoptosis, inflammation and fibrosis in the injured heart. Thus, CDC-derived exosomes represent a novel “cell-free” therapeutic candidate for tissue repair.
Claims20
A method of treatment, comprising:
- administering a composition comprising a plurality of exosomes to a subject in need of treatment for heart failure secondary to a chronic degenerative muscular disease, wherein the plurality of the exosomes are isolated from cardiosphere-derived cells (CDCs), and further wherein administration of the composition treats the subject.
11-17. (canceled)
A method of treatment, comprising:
- administering a composition comprising cardiosphere-derived cells (CDCs) to a subject in need of treatment for heart failure secondary to a chronic muscular disease, wherein administration of the composition treats the subject.
26-32. (canceled)
Dependencies are inferred from the claim text.