Template-induced silicate-doped hydroxyapatite and the preparation method
AssigneeAsia Biomaterials (Wuhan) Co., Ltd.
InventorsQin YANG, Yingying Du, Jianglin Wang
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Abstract
A silicate-doped hydroxyapatite material has an ordered and directional growth structure. The silicon content in the silicate-doped hydroxyapatite material ranges from 0.1 wt % to 1.6 wt %, and silicon is doped in hydroxyapatite lattices in a form of silicate. A template-induced method for manufacturing the synthetic silicate-doped hydroxyapatite material above.
Claims15
A silicate-doped hydroxyapatite material synthesized by a template-induced method using a template, wherein the silicate-doped hydroxyapatite material is grown orderly along a long axis of the template to have an ordered and directional growth structure, a content of a silicon in the silicate-doped hydroxyapatite material ranges from about 0.1 wt % to 1.6 wt %, and the silicon is doped in hydroxyapatite lattices of the silicate-doped hydroxyapatite material in a form of silicate.
A method for manufacturing a silicate-doped hydroxyapatite material, comprising:
- adjusting pH value of a calcium-containing solution to about pH 7.0;
- adding a silicon source slowly to the calcium-containing solution to form a silicon-calcium-containing solution;
- adding a phosphorus-containing solution dropwisely to the silicon-calcium-containing solution under stirring to form a reaction solution;
- adjusting pH value of the reaction solution to about pH 7.4, such that a reaction is performed in the reaction solution;
- and
- stopping stirring the reaction solution and let the reaction solution stand for a period of time so as to form a precipitate, collecting the precipitate, and washing and lyophilizing the precipitate to obtain the silicate-doped hydroxyapatite material.
Dependencies are inferred from the claim text.