Methods of Treatment
AssigneeGlaxoSmithKline Intellectual Property Development Limited
InventorsSoren BEINKE, Nikolai Nikolaevich BELYAEV, Edith HESSEL
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Abstract
The present invention relates to methods of treating or preventing respiratory infections, in particular respiratory infections in patients with an underlying respiratory disorder such as chronic obstructive pulmonary disease (COPD). The present invention also relates to methods of treating or preventing COPD or COPD exacerbations. The invention particularly describes the role of Notch 3 and/or Notch 4 signalling in such methods and the use of Notch 3 and/or Notch 4 as therapeutic and screening targets.
Claims12
A method of treating or preventing a respiratory infection which comprises inhibiting Notch 3 and/or Notch 4 signalling in a mammal.
A method of treating or preventing COPD which comprises inhibiting Notch 3 and/or Notch 4 signalling in a mammal.
A method of treating or preventing a COPD exacerbation which comprises inhibiting Notch 3 and/or Notch 4 signalling in a mammal.
11-13. (canceled)
A method of screening for an inhibitor of Notch 3 and/or Notch 4 signalling for use in treating or preventing respiratory infections, COPD or COPD exacerbations comprising the step of determining whether an agent inhibits the Notch 3 and/or Notch 4 pathway.
Dependencies are inferred from the claim text.