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US 2017/0290842 A1Published application
Rna polymerase i inhibitors and uses thereof
AssigneeTel HaShomer Medical Research Infrastructure and Services Ltd.
InventorsAnat ACHIRON, Roi MASHIACH, Michael GUREVICH
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Abstract
Provided are novel compounds which are capable of inhibiting an activity of RNA polymerase I, and uses thereof in treating diseases or disorders modulated by RNA polymerase I, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.
Claims10
A method of treating relapsing-remitting multiple sclerosis in a subject, the method comprising administering to the subject a therapeutically effective amount of the compound represented by Formula Ib:
- wherein G is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, alkoxy, thioalkoxy, thiol, hydroxyl, aryloxy, and thioaryloxy.
Dependencies are inferred from the claim text.