Substituted benzene compounds
AssigneeEpizyme, Inc.
InventorsKevin Wayne Kuntz, John Emmerson Campbell, Masashi Seki
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Abstract
The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Claims20
1-14. (canceled)
A method of treating or preventing an EZH2-mediated disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of
- and pharmaceutically acceptable salts thereof.
A method of modulating an activity of EZH2 or a mutant thereof, comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.