Arylquinazolines

A compound of formula (II)

• in which
• X is CH, CF, S or N,
• Y is CH, S or N,
• Z is C or N,
• n is 1 or 2, where
• if n=1, X=S, and if n=2, both X=CH, or the X linked to the pyrimidine ring is CF and the X not linked to the pyrimidine ring is CH, or one X is CH and the other X is N;
• m is 1 or 2, where
• if m=1, Y=S, and if m=2, both Y=CH, or one Y is CH and the other Y is N;
• R1 and R2 independently of one another, are H, Hal, CN, OH, CONH2, CONH(LA) or LA;
• R3 is Hal, CN, OH, CONH2, CONH(LA) or LA;
• R5 is H, Hal, CN or C≡CH,
• LA is unbranched or branched alkyl having 1-5 C atoms, which may be saturated or partially unsaturated, in which 1-3H atoms may be replaced by Hal, or one H atom may be replaced by CN or Het2, or one or two CH2 groups may be replaced by O, NH, N(CH3) or CO;
• Hal is F, Cl, Br or I;
• Cyc is Het1;
• Het1 is a mono- or bicyclic, 5-10-membered heterocycle, having 1-3 N, O or S atoms, or 1-4 N atoms, which may be monosubstituted by Het2;
• Het2 is a 3-5-membered aliphatic homo- or heterocycle having 0, 1, 2 or 3 N, O or S atoms, which is unsubstituted;
• R6′, R6″, independently of one another, are H, Hal, LA, oxo, CN, NH2 or Het2;
• Q1, Q2, independently of one another, are CH, N or NH and are in each case unsubstituted;
• and
• ---- denotes the presence or absence of double bonds in Cyc;
• or a physiologically acceptable salt, tautomer or stereoisomer thereof, including mixtures thereof in all ratios.

A compound of formula (IIa)

• in which
• Y is CH, S or N,
• R1 is H, Hal, CN, OH, CONH2, CONH(LA) or LA;
• LA is unbranched or branched alkyl having 1-5 C atoms, which may be saturated or partially unsaturated, in which 1-3H atoms may be replaced by Hal, or one H atom may be replaced by CN or Het2, or one or two CH2 groups may be replaced by O, NH, N(CH3) or CO;
• Hal is F, Cl, Br or I;
• R2, R3, independently of one another, are Hal, CN, OH, CONH2, CON(LA) or LA;
• R5 is H, Hal, CN or C≡CH,
• Cyc is Het1;
• Het1 is a mono- or bicyclic, 5-10-membered heterocycle, having 1-3 N, O or S atoms, or 1-4 N atoms, which may be monosubstituted by Het2;
• Het2 is a 3-5-membered aliphatic homo- or heterocycle having 0, 1, 2 or 3 N, O or S atoms, which is unsubstituted;
• R6′, R6″, independently of one another, are H, Hal, LA, oxo, CN, NH2 or Het2;
• Q1, Q2, independently of one another, are CH, N or NH and are in each case unsubstituted;
• X1 is CH, CF or N;
• X2 is CH or N,
• where X1, X2 are not simultaneously N;
• Y is CH or N;
• and
• ---- denotes the presence or absence of double bonds in Cyc;
• or a physiologically acceptable salt, tautomer or stereoisomer thereof, including mixtures thereof in all ratios.