Compositions and methods for increasing neurotrophic peptides
AssigneeSaint Louis College of Pharmacy
InventorJohn M. Beale
Life of this patent
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Abstract
A pharmaceutical composition is provided which includes a pharmaceutically acceptable excipient and a pharmaceutically and physically acceptable amount of a compound selected from the group consisting of Chemical Formulas I-IV as described herein, or a pharmaceutically acceptable salt thereof. Also provided are methods of increasing a level of a defined neurotrophic peptide in an organism or tissue comprising the administration of a pharmaceutically and physically acceptable amount of one or more of the compositions described above, and a method for treating a neurodegenerative disease in a subject in need thereof, the method comprising administering a therapeutically effective amount of the pharmaceutical composition of claim 1.
Claims6
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a pharmaceutically and physically acceptable amount of one or more compounds selected from the group consisting of:
- Chemical Formula I, wherein R1=H or CH3, R2=H or CH3, R3=H or OH, and R4=H or OH;
- Chemical Formula II, wherein R1=H or COCH3;
- Chemical Formula III, wherein R1=H or CH3 and R2=H or OH;
- and
- Chemical Formula IV, wherein R1=H or CH3 and R2=H or OH, or a pharmaceutically acceptable salt thereof.
2-15. (canceled)
17-25. (canceled)
27-35. (canceled)
Dependencies are inferred from the claim text.