Inhibitors of hepatitis c virus

A compound of Formula (I):

• or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein:
• J is J1, J2, J3, J4, J5, J6 J7, J8 or J9;
• {circle around (T)} is T1, T2, T3, T4, T5, T6, T7, T8, T9, T10, T11, T12, T13 or T14;
• L is L1, L2, L3, L4, L5, L6, L7, L8, L9 or L10;
• X is —O—, —CH2—, —OC(O)—, —C(O)O—, —C(O)—, —SO2—, —S(O)—, —N(R16)—, —S—, ═N—O— or a bond;
• A is —C(O)—, —S(O)2—, a 6-10 membered arylene, 5-10 membered heteroarylene, or 4-10 membered heterocyclene, wherein any of said arylene, heterocyclene, or heteroarylene is optionally substituted with 1-4 Z1 groups;
• M is a bond, C1-C5 alkylene, —O—, or —N(R16)—;
• R1 is H or F;
• R3, R4, and R5 are each independently selected from H or Z1;
• Q is Q1, Q2, Q3, Q4, Q5, Q6 or Q7;
• E is E1, E2, E3, E4, E5, or E6;
• G is —CO2H, —CONHSO2Z2, tetrazolyl, —CONHP(O)(R16)2, —P(O)(OH)(R16), and —P(O)(R16)2;
• {circle around (U)} is U1, U2, U3, U4, U5, U6 or U7;
• J1 is halogen;
• J2 is —OH and R1 is H;
• J3 is —NR17R18 and R1 is H;
• J1 is C1-C8 alkyl;
• J5 is C1-C8 alkyl substituted with 1-4 Z3 groups;
• J6 is C3-C8 carbocyclyl optionally substituted with 1-4 Z3 groups;
• J7 is C6-C10 aryl, 5-10 membered heteroaryl, or 4-10 membered heterocyclyl optionally substituted with 1-4 Z3 groups;
• J8 is C1-C8 alkoxy optionally substituted with 1-4 Z3 groups and R1 is H;
• J9 is C3-C8 carbocyclyloxy optionally substituted with 1-4 Z3 groups and R1 is H;
• T1 is C3-C8 carbocyclylene that is attached to L and M through two adjacent carbons;
• T2 is C3-C8 carcbocyclene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is substituted with 1-4 C1-C5 alkyl groups;
• T3 is C3-C8 carcbocyclene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is substituted with 1-4 halogen atoms and said carbocyclylene is optionally substituted with 1-4 C1-C5 alkyl groups;
• T4 is C3-C8 carbocyclene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is optionally substituted with a C1-C8 alkyl group, wherein said alkyl group is optionally substituted with 1-4 Z3 groups;
• T5 is 4-10 membered heterocyclene that is attached to L and M through two adjacent carbons;
• T6 is 4-10 membered heterocyclene that is attached to L through a carbon atom and attached to M through an N atom, wherein said heterocyclene is optionally substituted with 1-4 Z1 groups;
• T7 is 4-10 membered heterocyclene that is attached to M through a carbon atom and attached to L through an N atom, wherein said heterocyclene is optionally substituted with 1-4 Z1 groups;
• T8 is 4-10 membered heterocyclene that is attached to L and M through two adjacent carbons, wherein said heterocyclene is optionally substituted with 1-4 Z1 groups;
• T9 is C5-C12 spiro bicyclic carbocyclylene that is attached to L and M through two adjacent carbons, wherein said spiro bicyclic carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T10 is C5-C12 fused bicyclic carbocyclylene that is attached to L and M through two adjacent carbons, wherein said fused bicyclic carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T11 is C5-C12 bridged bicyclic carbocyclylene that is attached to L and M through two adjacent carbons, wherein said bridged bicyclic carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T12 is C4-C8 carbocylene that is attached to L and M through two non-adjacent carbons, wherein said carcbocyclene is optionally substituted with 1-4 Z1 groups;
• T13 is a 5-8 membered fused, bridged, or spiro bicyclic heterocyclene that is attached to L and M through two adjacent atoms, wherein said heterocyclene is optionally substituted with 1-4 Z1 groups;
• T14 is C3-C8 carbocyclylene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is optionally substituted with 1-4 Z4 groups;
• L1 is C1-C8 alkylene or C2-C8 alkenylene;
• L2 is C1-C8 alkylene or C2-C8 alkenylene wherein said C1-C8 alkylene is substituted with 1-4 halogens or said C2-C8 alkenylene is substituted with 1-4 halogens;
• L3 is C1-C8 alkylene or C2-C8 alkenylene wherein said C1-C8 alkylene is substituted with 1-4 Z4 groups or said C2-C8 alkenylene is substituted with 1-4 Z4 groups and wherein each is optionally substituted with 1-4 halogens;
• L4 is C1-C8 alkylene or C2-C8 alkenylene substituted with two geminal C1-C4 alkyl groups that come together to form a spiro C3-C8 carbocyclyl group, wherein L4 is optionally substituted with 1-4 Z1 groups;
• L5 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene that is connected to {circle around (T)} by an O, S or N atom and said heteroalkylene or heteroalkenylene is optionally substituted with 1-4 Z3 groups;
• L6 is 2-8 membered heteroalkylene or 5-8 membered heteroalkenylene that is connected to {circle around (T)} by a carbon atom and said heteroalkylene or heteroalkenylene is substituted with 1-4 halogen atoms and is optionally substituted with 1-4 Z1 groups;
• L7 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene that is connected to {circle around (T)} by a carbon atom and said heteroalkylene or heteroalkenylene is optionally substituted with 1-4 Z4 groups;
• L8 is L8A-L8B-L8C wherein L8A and L8C are each independently selected from C1-C6 alkylene, C1-C6 heteroalkylene, C2-C6 alkenylene or a bond and L8B is a 3- to 6-membered saturated or unsaturated ring containing 0 to 3 heteroatoms selected from N, O, or S, wherein L8A and L8C connect to L8B at two different ring atoms and L8B is optionally substituted with 1-4 Z1 groups;
• L9 is C2-C8 alkynylene optionally substituted with 1-4 Z1 groups;
• L10 is C1-C8 alkylene or C3-C8 alkenylene substituted with two geminal Z1 groups that come together to form a spiro 4-8 membered heterocyclyl group, wherein L10 is optionally substituted with 1-4 Z1 groups;
• U1 is C6-C14 membered arylene optionally substituted with 1-4 W groups;
• U2 is C3-C8 membered carbocyclylene optionally substituted with 1-4 W groups;
• U3 is 4-14 membered heterocyclene optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U4 is 5 or 6 membered monocyclic heteroarylene containing 1, 2 or 3 heteroatoms independently selected from N, O, or S, wherein said heteroarylene is optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U5 is 8, 9 or 10 membered fused bicyclic heteroarylene containing 1, 2 or 3 heteroatom ring atoms independently selected from N, O, or S, wherein said heteroarylene is optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U6 is 11-14 membered fused tricyclic heteroarylene containing 1, 2, 3 or 4 heteroatom ring atoms independently selected from N, O, or S, wherein said heteroarylene is optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U7 is 8-10 membered fused bicyclic heteroarylene containing 4 heteroatom ring atoms independently selected from N, O, or S, wherein said heteroaryl is optionally substituted with 1-2 W groups that are located on one or more ring atoms selected from C or N;
• W is independently W1, W2, W3, W4, W5, W6 or W7;
• W1 is oxo, halogen, —OR6, C1-C6 alkyl, —CN, —CF3, —SR6, —C(O)2R6, —C(O)N(R6)2, —C(O)R6, —N(R6)C(O)R6, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), C3-C8 carbocyclyl, C3-C8 cycloalkoxy, C1-C6 haloalkyl, —N(R6)2, —NR6(C1-C6 alkyl)O(C1-C6 alkyl), halo(C1-C6 alkoxy), —NR6SO2R6, —SO2N(R6)2, —NHCOOR6, —NHCONHR6, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl or —O(4-10 membered heterocyclyl), wherein said W1 alkyl, carbocyclyl, cycloalkoxy, haloalkyl, haloalkoxy, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1-4 Z1c groups;
• each R6 is independently selected from H, C6-C10 aryl or C1-C6 alkyl, wherein said aryl or alkyl is optionally substituted with 1 to 4 substituents independently selected from halogen atoms, C1-C6 alkyl, C6-C10 aryl, C3-C8 carbocyclyl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, halo(C1-C6 alkoxy), —OH, —O(C1-C5 alkyl), —SH, —S(C1-C6 alkyl), —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —C(O)(C1-C6 alkyl), —SO2N(C1-C6 alkyl)2, —NHCOO(C1-C6 alkyl), —NHCO(C1-C6 alkyl), —NHCONH(C1-C6 alkyl), —CO2(C1-C6 alkyl), or —C(O)N(C1-C6 alkyl)2;
• W2 is C1-C6 alkoxy substituted with a 5-14 membered heteroaryl or C6-C10 aryl;
• wherein said heteroaryl or aryl is substituted with 1-4 Z1 groups;
• W3 is C2-C6 alkynyl substituted with an C6-C10 aryl, C3-C8 carbocyclyl, C1-C8 alkyl, C1-C6 haloalkyl, 4-10 membered heterocyclyl, or 5-14 membered heteroaryl;
• wherein said aryl, carbocyclyl, alkyl, haloalkyl, heterocyclyl, or heteroaryl is optionally substituted with 1-4 Z1 groups;
• W4 is —SF5;
• W5 is —O(C2-C6 alkyl)OR22 wherein R22 is an C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, and wherein said aryl, heteroaryl or heterocyclyl is optionally substituted with 1-4 Z1 groups;
• W6 is —O(C2-C6 alkyl)NR16R22 wherein R22 is an C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, and wherein said aryl, heteroaryl or heterocyclyl is optionally substituted with 1-4 Z1 groups;
• W7 is —O(5-14 membered heteroaryl);
• wherein said —O(5-14 membered heteroaryl) is optionally substituted with 1-4 Z1 groups;
• E1 is C2-C6 alkenyl;
• E2 is C1-C6 alkyl;
• E3 is C1-C6 haloalkyl;
• E4 is C2-C6 haloalkenyl;
• E5 is C3-C5 carbocyclyl;
• E8 is C1-C6 alkyl substituted with —OCH3, -OCD3, —OCF3, or —OCF2H;
• Q1 is H, C1-C8 alkyl, C3-C8 carbocyclyl, C6-C10 aryl, 5-6 membered heteroaryl, or 5-6 membered heterocyclyl, wherein when Q1 is not H, said Q1 is optionally substituted with 1-3 substituents independently selected from halogen, —OR6, —SR6, —N(R6)2, C6-C10 aryl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, —CN, —CF3, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —NR6SO2Z2, —SO2NR17R18, —NHCOOR16, —NHCOZ2, —NHCONHR16, —CO2R6, —C(O)R6, or —CON(R6)2;
• Q2 is C5-C10 spiro bicyclic carbocyclyl optionally substituted with 1-4 Z1 groups;
• Q3 is C5-C10 fused bicyclic carbocyclyl optionally substituted with 1-4 Z1 groups;
• Q4 is C5-C10 bridged bicyclic carbocyclyl optionally substituted with 1-4 Z1 groups;
• Q5 is 4-membered heterocyclyl having 1 heteroatom selected from N, O or S wherein Q5 is optionally substituted with 1-4 Z3 groups;
• Q6 is C1-C8 alkyl, C3-C8 carbocyclyl, C6-C10 aryl, 5-6 membered heteroaryl, or 5-6 membered heterocyclyl, wherein Q6 is substituted with 1 oxo group and with 0 to 3 substituents independently selected from halogen, —OR6, —SR6, —N(R6)2, C6-C10 aryl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, —NO2, —CN, —CF3, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —NR6SO2Z2, —SO2NR17R18, —NHCOOR16, —NHCOZ2, —NHCONHR16, —CO2R6, —C(O)R6, or —CON(R6)2;
• Q7 is C3-C8 carbocyclyl, wherein Q7 is substituted with 4-8 F atoms and each carbon of Q7 is substituted with 0-2 F atoms;
• each Z1 is independently oxo, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C6 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)R16, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)R16, —NR16C(O)NR17R18, —NR16S(O)2R16, —NR16S(O)2NR17R18, —NR16S(O)2OR16, —OR16, —OC(O)R16, —OC(O)NR17R18, —SR16, —S(O)R16, —S(O)2R16 or —S(O)2NR17R18 wherein any alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of Z1 is optionally substituted with 1-4 Z1a groups;
• each Z1a is independently oxo, halogen, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)R16, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)R16, —NR16C(O)OR16, —NR16C(O)NR17R18, —NR16S(O)2R16, —NR16S(O)2NR17R18, —NR16S(O)2OR16, —OR16, —OC(O)R16, —OC(O)NR17R18, —SR16, —S(O)R16, —S(O)2R16 or —S(O)2NR17R18 wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of Z1a is optionally substituted with 1-4 Z1c groups;
• each R16 is independently H, C1-C8 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, wherein any alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of R16 is optionally substituted with 1-4 Z1c groups;
• each Z1c is independently oxo, halogen, C1-C8 alkyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)(C1-C8 alkyl), —C(O)O(C1-C8 alkyl), —C(O)N(C1-C8 alkyl)2, —NH2, —NH(C1-C8 alkyl), —N(C1-C8 alkyl)2, —NHC(O)O(C1-C8 alkyl), —NHC(O)(C1-C8 alkyl), —NHC(O)NH(C1-C8 alkyl), —OH, —O(C1-C8 alkyl), C3-C8 cycloalkoxy, C5-C10 bicyclic carbocyclyloxy, —S(C1-C8 alkyl) or —S(O)2N(C1-C8 alkyl)2 wherein any alkyl, carbocyclyl, aryl, heteroaryl, heterocyclyl or cycloalkoxy portion of Z1c is optionally substituted with 1-4 halogen atoms or C1-C6 alkoxy groups;
• R17 and R18 are each independently H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, —C(O)R16, —C(O)OR16, C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, wherein any alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of R17 or R18 is optionally substituted with 1-4 Z1c groups, or R17 and R18 together with the nitrogen to which they are attached form a 4-7 membered heterocyclyl group, wherein said 4-7 membered heterocyclyl group is optionally substituted with 1-4 Z1c groups;
• each Z2 is independently C1-C8 alkyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —NR17R18 or —OR16 wherein any alkyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portion of Z2 is optionally substituted with 1-4 Z2a groups;
• each Z2a is independently oxo, halogen, C1-C8 alkyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —(C2-C8 alkynyl)aryl, —(C2-C8 alkynyl)heteroaryl, —CN, —C(O)(C1-C6 alkyl), —C(O)O(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)2, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —NHC(O)O(C1-C6 alkyl), —NHC(O)(C1-C6 alkyl), —NHC(O)NH(C1-C6 alkyl), —OH, —O(C1-C6 alkyl), halo(C1-C6 alkoxy), C3-C8 cycloalkoxy, —S(C1-C6 alkyl), or —SO2N(C1-C6 alkyl)2;
• wherein any alkyl, alkynyl, carbocyclyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl portions of Z2a is optionally substituted with 1-4 halogen or C1-C6 alkoxy groups;
• each Z3 is independently oxo, halogen, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR18C(O)NR17R18, —OR16, —SR16 or —SO2R16;
• wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portions of Z3 is optionally substituted with 1-4 halogen;
• and
• each Z4 is independently oxo, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)NR17R18, —OR16, —SR16 or —SO2R16, wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portions of Z4 is optionally substituted with 1-4 halogen.

A compound of Formula (II):

• or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein:
• M is —O—;
• J is J1, J2, J3, J4, J5, J6, J7, J8 or J9;
• {circle around (T)} is T1, T2, T3, T4, T5, T7, T8, T9, T10, T11, T12, T13 or T14;
• L is L1, L2, L3, L4, L5, L6, L7, L8, L9 or L10;
• R1 is H or F;
• Q is Q1, Q2, Q3, Q4, Q5, Q6 Or Q7;
• E is E1, E2, E3, E4, E5, or E6;
• {circle around (U)} is U1, U2, U3, U4, U5, U6 or U7;
• J1 is halogen;
• J2 is —OH and R1 is H;
• J3 is —NR17R18 and R1 is H;
• J4 is C1-C8 alkyl;
• J5 is C1-C8 alkyl optionally substituted with 1-4 Z3 groups;
• J6 is C3-C8 carbocyclyl optionally substituted with 1-4 Z3 groups;
• J7 is C6-C10 aryl, 5-14 membered heteroaryl, or 4-10 membered heterocyclyl, any of which are optionally substituted with 1-4 Z3 groups;
• J8 is C1-C8 alkoxy optionally substituted with 1-4 Z3 groups and R1 is H;
• J9 is C3-C8 carbocyclyloxy optionally substituted with 14 Z3 groups and R1 is H;
• T1 is C3-C8 carbocyclylene that is attached to L and M through two adjacent carbons;
• T2 is C3-C8 carbocyclylene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is optionally substituted with 1-4 C1-C8 alkyl groups;
• T3 is C3-C8 carbocyclylene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is optionally substituted with 1-4 halogen atoms and said carbocyclylene is optionally substituted with 1-4 C1-C6 alkyl groups;
• T4 is C3-C8 carbocyclylene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is optionally substituted with a C1-C8 alkyl group, wherein said alkyl group is optionally substituted with 1-4 Z3 groups;
• T5 is 4-10 membered heterocyclene that is attached to L and M through two adjacent carbons;
• T7 is 4-10 membered heterocyclene that is attached to M through a carbon atom and attached to L through a N atom, wherein said heterocyclene is optionally substituted with 1-4 Z1 groups;
• T8 is 4-10 membered heterocyclene that is attached to L and M through two adjacent carbons, wherein said heterocyclene is optionally substituted with 1-4 Z1 groups;
• T9 is C5-C12 spiro bicyclic carbocyclylene that is attached to L and M through two adjacent carbons, wherein said spiro bicyclic carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T10 is C5-C12 fused bicyclic carbocyclylene that is attached to L and M through two adjacent carbons, wherein said fused bicyclic carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T11 is C5-C12 bridged bicyclic carbocyclylene that is attached to L and M through two adjacent carbons, wherein said bridged bicyclic carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T12 is C4-C8 carbocyclylene that is attached to L and M through two non-adjacent carbons, wherein said carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T13 is a 5-8 membered fused, bridged, or spiro bicyclic heterocyclene that is attached to L and M through two adjacent atoms, wherein said heterocyclene is optionally substituted with 1-4 Z1 groups;
• T14 is C3-C8 carbocyclylene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is optionally substituted with 1-4 Z4 groups;
• L1 is C1-C8 alkylene or C2-C8 alkenylene;
• L2 is C1-C8 alkylene or C2-C8 alkenylene wherein said C1-C8 alkylene is substituted with 14 halogens or said C2-C8 alkenylene is substituted with 1-4 halogens;
• L3 is C1-C8 alkylene or C2-C8alkenylene wherein said C1-C8 alkylene is substituted with 1-4 Z4 groups or said C2-C8 alkenylene is substituted with 1-4 Z4 groups and wherein each is optionally substituted with 1-4 halogens;
• L4 is C1-C8 alkylene or C2-C8 alkenylene substituted with two geminal C1-C4 alkyl groups that come together to form a spiro C3-C8 carbocyclyl group, wherein L4 is optionally substituted with 1-4 Z1 groups;
• L5 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene that is connected to {circle around (T)} by an O, S or N atom and said heteroalkylene or heteroalkenylene is optionally substituted with 1-4 Z3 groups;
• L6 is 2-8 membered heteroalkylene or 5-8 membered heteroalkenylene that is connected to {circle around (T)} by a carbon atom and said heteroalkylene or heteroalkenylene is substituted with 1-4 halogen atoms and is optionally substituted with 1-4 Z4 groups;
• L7 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene that is connected to {circle around (T)} by a carbon atom and said heteroalkylene or heteroalkenylene is optionally substituted with 1-4 Z4 groups;
• L8 is L8A-L8B-L8C wherein L8A and L8C are each independently selected from C1-C6 alkylene, C1-C6 heteroalkylene, C2-C6 alkenylene or a bond and La is a 3- to 6-membered saturated or unsaturated ring containing 0 to 3 heteroatoms selected from N, O, or S, wherein L8A and L8C connect to L8B at two different ring atoms and L8B is optionally substituted with 1-4 Z1 groups;
• L9 is C2-C8 alkynylene optionally substituted with 1-4 Z1 groups;
• L10 is C1-C6 alkylene or C3-C8 alkenylene substituted with two geminal Z1 groups that come together to form a spiro 4-8 membered heterocyclyl group, wherein L10 is optionally substituted with 1-4 Z1 groups;
• U1 is C6-C14 membered arylene optionally substituted with 1-4 W groups;
• each U2 is C3-C8 membered carbocyclylene optionally substituted 1-4 W groups;
• each U3 is 4-14 membered heterocyclene optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U4 is 5 or 6 membered monocyclic heteroarylene containing 1, 2 or 3 heteroatoms independently selected from N, O, or S, wherein said heteroarylene is optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U5 is 8, 9 or 10 membered fused bicyclic heteroarylene containing 1, 2 or 3 heteroatom ring atoms independently selected from N, O, or S, wherein said heteroarylene is optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U6 is 11-14 membered fused tricyclic heteroarylene containing 1, 2, 3 or 4 heteroatom ring atoms independently selected from N, O, or S, wherein said heteroarylene is optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U7 is 8-10 membered fused bicyclic heteroarylene containing 4 heteroatom ring atoms independently selected from N, O, or S, wherein said heteroaryl is optionally substituted with 1-2 W groups that are located on one or more ring atoms selected from C or N;
• each W is independently W1, W2, W3, W4, W5, W6 or W7;
• each W1 is oxo, halogen, —OR8, C1-C6 alkyl, —CN, —CF3, —SR6, —C(O)2R6, —C(O)N(R6)2, —C(O)R6, —N(R6)C(O)R6, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), C3-C8 carbocyclyl, C3-C8 cycloalkoxy, C1-C6 haloalkyl, —N(R6)2, —NR6(C1-C6 alkyl)O(C1-C6 alkyl), halo(C1-C6 alkoxy), —NR6SO2R6, —SO2N(R6)2, —NHCOOR6, —NHCONHR6, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl or —O(4-10 membered heterocyclyl), wherein said W1 alkyl, carbocyclyl, cycloalkoxy, haloalkyl, haloalkoxy, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1-4 Z1c groups;
• each R6 is independently selected from H, C6-C10 aryl or C1-C6 alkyl, wherein said aryl or alkyl is optionally substituted with 1 to 4 substituents independently selected from halogen atoms, C1-C6 alkyl, C6-C10 aryl, C3-C8 carbocyclyl, 5-14 membered heteroaryl, 4-membered heterocyclyl, halo(C1-C6 alkoxy), —OH, —O(C1-C6 alkyl), —SH, —S(C1-C6 alkyl), —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —C(O)(C1-C6 alkyl), —SO2N(C1-C6 alkyl)2, —NHCOO(C1-C6 alkyl), —NHCO(C1-C6 alkyl), —NHCONH(C1-C6 alkyl), —CO2(C1-C6 alkyl), or —C(O)N(C1-C6 alkyl)2;
• each W2 is C1-C6 alkoxy substituted with a 5-14 membered heteroaryl or C6-C10 aryl;
• wherein said heteroaryl or aryl is substituted with 1-4 Z1c groups;
• each W3 is C2-C6 alkynyl substituted with an C6-C10 aryl, C3-C8 carbocyclyl, C1-C8 alkyl, C1-C6 haloalkyl, 4-10 membered heterocyclyl, or 5-14 membered heteroaryl;
• wherein said aryl, carbocyclyl, alkyl, haloalkyl, heterocyclyl, or heteroaryl is optionally substituted with 1-4 Z1 groups;
• each W4 is —SF5;
• each W5 is —O(C2-C6 alkyl)OR2 wherein R22 is an C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl optionally substituted with 1-4 Z1 groups;
• each W6 is —O(C2-C6 alkyl)NR16R22 wherein R22 is an C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl optionally substituted with 1-4 Z1 groups;
• each W7 is —O(5-14 membered heteroaryl);
• wherein said —O(5-14 membered heteroaryl) is optionally substituted with 1-4 Z1 groups and 2 adjacent substituents of said —O(5-14 membered heteroaryl) may be taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms independently selected from N, O, or S;
• E1 is C2-C6 alkenyl;
• E2 is C1-C6 alkyl;
• E3 is C1-C6 haloalkyl;
• E4 is C2-C6 haloalkenyl;
• E5 is C3-C6 carbocyclyl;
• E8 is C1-C6 alkyl optionally substituted with —OCH3, -OCD3, —OCF3, or —OCF2H;
• Q1 is selected from H, C1-C8 alkyl, C3-C8 carbocyclyl, C6-C10 aryl, 5-6 membered heteroaryl, or 5-6 membered heterocyclyl groups, wherein when Q1 is not H, said Q1 is optionally substituted with 1-4 substituents independently selected from halogen, —OR6, —SR6, —N(R6)2, C6-C10 aryl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C5 haloalkoxy, —NO2, —CN, —CF3, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —NR6SO2Z2, —SO2NR17R18, —NHCOOR16, —NHCOZ2, —NHCONHR18, —CO2R6, —C(O)R6, and —CON(R6)2;
• Q2 is C5-C10 spiro bicyclic carbocyclyl optionally substituted with 1-4 Z1 groups;
• Q3 is C5-C10 fused bicyclic carbocyclyl optionally substituted with 1-4 Z1 groups;
• Q4 is C5-C10 bridged bicyclic carbocyclyl optionally substituted with 1-4 Z1 groups;
• Q5 is 4-membered heterocyclyl having 1 heteroatom selected from N, O or S wherein Q5 is optionally substituted with 1-4 Z3 groups;
• Q6 is C1-C8 alkyl, C3-C8 carbocyclyl, C6-C10 aryl, 5-6 membered heteroaryl, or 5-6 membered heterocyclyl, wherein Q6 is substituted with 1 oxo group and with 0 to 3 substituents independently selected from halogen, —OR6, —SR6, —N(R6)2, C6-C10 aryl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, —NO2, —CN, —CF3, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —NR6SO2Z2, —SO2NR17R16, —NHCOOR16, —NHCOZ2, —NHCONHR16, —CO2R6, —C(O)R6, or —CON(R6)2;
• Q7 is C3-C8 carbocyclyl, wherein Q7 is substituted with 4-8 F atoms and each carbon of Q7 is substituted with 0-2 F atoms;
• each Z1 is independently oxo, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)R16, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)R16, —NR16C(O)NR17R18, —NR16S(O)2R16, —NR16S(O)2NR17R18, —NR16S(O)2OR16, —OR16, —OC(O)R16, —OC(O)NR17R18, —SR16, —S(O)R16, —S(O)2R16 or —S(O)2NR17R18 wherein any alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of Z1 is optionally substituted with 1-4 Z1a groups;
• each Z18 is independently oxo, halogen, C2-C5 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C5 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)R16, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)R16, —NR16C(O)OR16, —NR16C(O)NR17R18, —NR16S(O)2R16, —NR16S(O)2NR17R18, —NR16S(O)2OR16, —OR16, —OC(O)R16, —OC(O)N R17R18, —SR16, —S(O)R16, —S(O)2R16 or —S(O)2NR17R18 wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of Z1a is optionally substituted with 1-4 Z1c groups;
• each R16 is independently H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, wherein any alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of R16 is optionally substituted with 1-4 Z1c groups;
• each Zc is independently oxo, halogen, C1-C8 alkyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)(C1-C8 alkyl), —C(O)O(C1-C8 alkyl), —C(O)N(C1-C8 alkyl)2, —NH2, —NH(C1-C8 alkyl), —N(C1-C8 alkyl)2, —NHC(O)O(C1-C8 alkyl), —NHC(O)(C1-C8 alkyl), —NHC(O)NH(C1-C8 alkyl), —OH, —O(C1-C8 alkyl), C3-C8 cycloalkoxy, C5-C10 bicyclic carbocyclyloxy, —S(C1-C8 alkyl) or —S(O)2N(C1-C8 alkyl)2 wherein any alkyl, carbocyclyl, aryl, heteroaryl, heterocyclyl or cycloalkoxy portion of Z1c is optionally substituted with 1-4 halogen atoms or C1-C6 alkoxy groups;
• R17 and R18 are each independently H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, —C(O)R16, —C(O)OR16, C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, wherein any alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of R17 or R18 is optionally substituted with 1-4 Z1c groups, or R17 and R18 together with the nitrogen to which they are attached form a 4-7 membered heterocyclyl group, wherein said 4-7 membered heterocyclyl group is optionally substituted with 1-4 Z1c groups;
• each Z2 is independently C1-C8 alkyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —NR17R18 or —OR16 wherein any alkyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portion of Z2 is optionally substituted with 1-4 Z2a groups;
• each Z2a is independently oxo, halogen, C1-C8 alkyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C8-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —(C2-C8 alkynyl)aryl, —(C2-C8 alkynyl)heteroaryl, —CN, —C(O)(C1-C6 alkyl), —C(O)O(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)2, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —NHC(O)O(C1-C6 alkyl), —NHC(O)(C1-C6 alkyl), —NHC(O)NH(C1-C6 alkyl), —OH, —O(C1-C6 alkyl), halo(C1-C6 alkoxy), C3-C8 cycloalkoxy, —S(C1-C6 alkyl), or —SO2N(C1-C6 alkyl)2;
• wherein any alkyl, alkynyl, carbocyclyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl portions of Z2a is optionally substituted with 1-4 halogen or C1-C6 alkoxy groups;
• each Z3 is independently oxo, halogen, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)NR17R18, —OR16, —SR16 or —SO2R16;
• wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portions of Z3 is optionally substituted with 1-4 halogen;
• and
• each Z4 is independently oxo, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)NR17R18, —OR16, —SR16 or —SO2R18, wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portions of Z4 is optionally substituted with 1-4 halogen.

A compound of Formula (III):

• or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein:
• M is —O—;
• J is J1, J2, J3, J4, J5, J6, J7, J8 or J9;
• {circle around (T)} is T1, T2, T3, T4, T5, T7, T8, T9, T10, T11, T12, T13 or T14;
• L is L1, L2, L3, L4, L5, L6, L7, L8, L9 or L10;
• Q is Q1, Q2, Q3, Q4, Q5 or Q7;
• E is E1, E2, E3, or E4;
• {circle around (U)} is selected from U1, U3, U4, U5, U6 or U7;
• J1 is halogen;
• J2 is —OH;
• J3 is —NR17R18;
• J1 is C1-C5 alkyl;
• J5 is C1-C8 alkyl substituted with 1-4 Z3 groups;
• J6 is C3-C8 carbocyclyl optionally substituted with 1-4 Z3 groups;
• J7 is C6-C10 aryl, 5-14 membered heteroaryl, or 4-10 membered heterocyclyl any of which groups are optionally substituted with 1-4
• Z3 groups;
• J8 is C1-C8 alkoxy optionally substituted with 1-4 Z3 groups;
• J9 is C3-C8 carbocyclyloxy optionally substituted with 1-4 Z3 groups;
• T1 is C3-C8 carbocyclylene attached to L and M through two adjacent carbons;
• T2 is C3-C8 carbocyclylene attached to L and M through two adjacent carbons, wherein said carbocyclylene is substituted with 1-4 C1-C8 alkyl groups;
• T3 is C3-C8 carbocyclylene attached to L and M through two adjacent carbons, wherein said carbocyclylene is substituted with 14 halogen atoms and said carbocyclylene is optionally substituted with 1-4 C1-C6 alkyl groups;
• T4 is C3-C8 carbocyclylene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is substituted with a C1-C8 alkyl group, wherein said alkyl group is substituted with 1-4 Z3 groups;
• T5 is 4-10 membered heterocyclene that is attached to L and M through two adjacent carbons;
• T7 is 4-10 membered heterocyclene that is attached to M through a carbon atom and attached to L through a N atom, wherein said heterocyclene is optionally substituted with 1-4 Z1 groups;
• T8 is 4-10 membered heterocyclene that is attached to L and M through two adjacent carbons, wherein said heterocyclene is substituted with 1-4 Z1 groups;
• T9 is C5-C12 spiro bicyclic carbocyclylene that is attached to L and M through two adjacent carbons, wherein said spiro bicyclic carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T10 is C5-C12 fused bicyclic carbocyclylene that is attached to L and M through two adjacent carbons, wherein said fused bicyclic carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T11 is C5-C12 bridged bicyclic carbocyclylene that is attached to L and M through two adjacent carbons, wherein said bridged bicyclic carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T12 is C4-C8 carbocyclylene that is attached to L and M through two non-adjacent carbons, wherein said carbocyclylene is optionally substituted with 1-4 Z1 groups;
• T13 is a 5-8 membered fused, bridged, or spiro bicyclic heterocyclene that is attached to L and M through two adjacent atoms, wherein said heterocyclene is optionally substituted with 1-4 Z1 groups;
• T14 is C3-C8 carbocyclylene that is attached to L and M through two adjacent carbons, wherein said carbocyclylene is substituted with 1-4 Z4 groups;
• L1 is C1-C8 alkylene or C2-C8 alkenylene;
• L2 is C1-C8 alkylene or C2-C8 alkenylene wherein said C1-C8 alkylene or said C2-C8 alkenylene is substituted with 1-4 halogens;
• L3 is C1-C8 alkylene or C2-C8 alkenylene wherein said C1-C8 alkylene or said C2-C8 alkenylene and wherein said C1-C8 alkylene or said C2-C8 alkenylene is optionally substituted with 1-4 halogens;
• L4 is C1-C8 alkylene or C2-C8 alkenylene substituted with two geminal C1-C4 alkyl groups that come together to form a spiro C3-C8 carbocyclyl group, wherein L4 is optionally substituted with 1-4 Z1 groups;
• L5 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene that is connected to {circle around (T)} by an O, S or N atom and said heteroalkylene or heteroalkenylene is optionally substituted with 1-4 Z3 groups;
• L6 is 2-8 membered heteroalkylene or 5-8 membered heteroalkenylene that is connected to {circle around (T)} by a carbon atom and said heteroalkylene or heteroalkenylene is substituted with 1-4 halogen atoms and is optionally substituted with 1-4 Z4 groups;
• L7 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene that is connected to {circle around (T)} by a carbon atom and said heteroalkylene or heteroalkenylene is optionally substituted with 1-4 Z4 groups;
• L8 is L8A-L8B-L8C wherein L8A and L8C are each independently C1-C8 alkylene, C1-C6 heteroalkylene, C2-C6 alkenylene or a bond and La is a 3- to 6-membered saturated or unsaturated ring containing 0 to 3 heteroatoms selected from N, O, or S, wherein L8A and L8C connect to L8B at two different ring atoms and L8B is optionally substituted with 1-4 Z1 groups;
• L9 is C2-C8 alkynylene optionally substituted with 1-4 Z1 groups;
• L10 is C1-C8 alkylene or C3-C8 alkenylene substituted with two geminal Z1 groups that come together to form a spiro 4-8 membered heterocyclyl group, wherein L10 is optionally substituted with 1-4 Z1 groups;
• U1 is a C6-C14 membered arylene optionally substituted with 1-4 W groups;
• U3 is a 4-14 membered heterocyclene optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U4 is a 5 or 6 membered monocyclic heteroarylene containing 1, 2 or 3 heteroatoms independently selected from N, O, or S, wherein said heteroarylene is optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U5 is a 8, 9 or 10 membered fused bicyclic heteroarylene containing 1, 2 or 3 heteroatom ring atoms independently selected from N, O, or S, wherein said heteroarylene is optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U6 is a 11-14 membered fused tricyclic heteroarylene containing 1, 2, 3 or 4 heteroatom ring atoms independently selected from N, O, or S, wherein said heteroarylene is optionally substituted with 1-4 W groups that are located on one or more ring atoms selected from C or N;
• U7 is a 8-10 membered fused bicyclic heteroarylene containing 4 heteroatom ring atoms independently selected from N, O, or S, wherein said heteroaryl is optionally substituted with 1-2 W groups that are located on one or more ring atoms selected from C or N;
• each W is independently W1, W2, W3, W4, W5, W6 or W7;
• each W1 is independently oxo, halogen, —OR6, C1-C6 alkyl, —CN, —CF3, —SR6, —C(O)2R6, —C(O)N(R6)2, —C(O)R6, —N(R6)C(O)R6, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), C3-C8 carbocyclyl, C3-C8 cycloalkoxy, C1-C6 haloalkyl, —N(R6)2, —NR6(C1-C6 alkyl)O(C1-C6 alkyl), halo(C1-C6 alkoxy), —NR6SO2R6, —SO2N(R6)2, —NHCOOR6, —NHCONHR6, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl or —O(4-10 membered heterocyclyl), wherein said W1 alkyl, carbocyclyl, cycloalkoxy, haloalkyl, haloalkoxy, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1-4 Z1c groups;
• each R6 is independently H, C6-C10 aryl or C1-C6 alkyl, wherein said aryl or alkyl is optionally substituted with 1 to 4 substituents independently selected from halogen atoms, C1-C6 alkyl, C6-C10 aryl, C3-C8 carbocyclyl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, halo(C1-C6 alkoxy), —OH, —O(C1-C6 alkyl), —SH, —S(C1-C8 alkyl), —NH2, —NH(C1-C6 alkyl), —N(C1-C8 alkyl)2, —C(O)(C1-C6 alkyl), —SO2N(C1-C6 alkyl)2, —NHCOO(C1-C6 alkyl), —NHCO(C1-C6 alkyl), —NHCONH(C1-C6 alkyl), —CO2(C1-C6 alkyl), or —C(O)N(C1-C6 alkyl)2;
• each W2 is C1-C6 alkoxy substituted with a 5-14 membered heteroaryl or C6-C10 aryl;
• wherein said heteroaryl or aryl is substituted with 1-4 Z1 groups;
• each W3 is C2-C6 alkynyl group substituted with a C6-C10 aryl, C3-C8 carbocyclyl, C1-C8 alkyl, C1-C6 haloalkyl, 4-10 membered heterocyclyl, or 5-14 membered heteroaryl group;
• wherein said aryl, carbocyclyl, alkyl, haloalkyl, heterocyclyl, or heteroaryl group is optionally substituted with 1-4 Z1 groups;
• each W4 is —SF5;
• each W5 is —O(C2-C6 alkyl)OR22 wherein R22 is a C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl group optionally substituted with 1-4 Z1 groups;
• each W6 is —O(C2-C6 alkyl)NR16R22 wherein R22 is an aryl, heteroaryl or heterocyclyl group optionally substituted with 1-4 Z1 groups;
• each W7 is —O(5-14 membered heteroaryl);
• wherein said —O(5-14 membered heteroaryl) is optionally substituted with 1-4 Z1 groups and 2 adjacent substituents of said —O(5-14 membered heteroaryl) may be taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms independently selected from N, O, or S;
• E1 is
• E2 is
• E3 is
• E4 is
• Q1 is H, C1-C8 alkyl, C3-C8 carbocyclyl, C6-C10 aryl, 5-6 membered heteroaryl, or 5-6 membered heterocyclyl groups, wherein when Q1 is not H, said Q1 is optionally substituted with 1-4 substituents independently selected from halogen, —OR6, —SR6, —N(R6)2, C6-C10 aryl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C5 haloalkoxy, —CN, —CF3, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —NR6SO2Z2, —SO2NR17R18, —NHCOOR16, —NHCOZ2, —NHCONHR16, —CO2R6, —C(O)R6 or —CON(R6)2;
• Q2 is C5-C10 spiro bicyclic carbocyclyl optionally substituted with 1-4 Z1 groups;
• Q3 is C5-C10 fused bicyclic carbocyclyl optionally substituted with 1-4 Z1 groups;
• Q4 is C5-C10 bridged bicyclic carbocyclyl optionally substituted with 1-4 Z1 groups;
• Q5 is 4-membered heterocyclyl having 1 heteroatom selected from N, O or S wherein Q5 is optionally substituted with 1-4 Z3 groups;
• Q7 is C3-C8 carbocyclyl substituted with 4-8 F atoms and each carbon of Q7 is substituted with 0-2 F atoms;
• each Z1 is independently oxo, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)R18, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)R16, —NR16C(O)NR17R18, —NR16S(O)2R16, —NR16S(O)2NR17R18, —NR16S(O)2OR16, —OR16, —OC(O)R16, —OC(O)NR17R18, —SR18, —S(O)R16, —S(O)2R16 Or —S(O)2NR17R18 wherein any alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of Z1 is optionally substituted with 1-4 Z1a groups;
• each Z1a is independently oxo, halogen, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)R11, —C(O)OR16, —C(O)NR17R18, —NR17R18,
• —NR16C(O)R16, —NR16C(O)OR16, —NR16C(O)NR17R18, —NR16S(O)2R16, —NR16S(O)2NR17R18, —NR16S(O)2OR16, —OR16, —OC(O)R16, —OC(O)NR17R18, —SR16, —S(O)R16, —S(O)2R16 or —S(O)2NR17R18 wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of Z1a is optionally substituted with 1-4 Z1c groups;
• each R18 is independently H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, wherein any alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of R16 is optionally substituted with 1-4 Z1c groups;
• each Z1c is independently oxo, halogen, C1-C8 alkyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)(C1-C8 alkyl), —C(O)O(C1-C8 alkyl), —C(O)N(C1-C8 alkyl)2, —NH2, —NH(C1-C8 alkyl), —N(C1-C8 alkyl)2, —NHC(O)O(C1-C8 alkyl), —NHC(O)(C1-C8 alkyl), —NHC(O)NH(C1-C8 alkyl), —OH, —O(C1-C8 alkyl), C3-C8 cycloalkoxy, C5-C10 bicyclic carbocyclyloxy, —S(C1-C8 alkyl) or —S(O)2N(C1-C8 alkyl)2 wherein any alkyl, carbocyclyl, aryl, heteroaryl, heterocyclyl or cycloalkoxy portion of Z1c is optionally substituted with 1-4 halogen atoms or C1-C6 alkoxy groups;
• R17 and R18 are each independently H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, —C(O)R16, —C(O)OR16, C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, wherein any alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of R17 or R18 is optionally substituted with 1-4 Z1c groups, or R17 and R18 together with the nitrogen to which they are attached form a 4-7 membered heterocyclyl group, wherein said 4-7 membered heterocyclyl group is optionally substituted with 1-4 Z1c groups;
• each Z2 is independently C1-C8 alkyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —NR17R18 or —OR16 wherein any alkyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portion of Z2 is optionally substituted with 1-4 Z2a groups;
• each Z2a is independently oxo, halogen, C1-C6 alkyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —(C2-C8 alkynyl)aryl, —(C2-C8 alkynyl)heteroaryl, —CN, —C(O)(C1-C6 alkyl), —C(O)O(C1-C6alkyl), —C(O)N(C1-C6 alkyl)2, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —NHC(O)O(C1-C6 alkyl), —NHC(O)(C1-C6 alkyl), —NHC(O)NH(C1-C6 alkyl), —OH, —O(C1-C6 alkyl), halo(C1-C6 alkoxy), C3-C8 cycloalkoxy, —S(C1-C6 alkyl), or —SO2N(C1-C6 alkyl)2;
• wherein any alkyl, alkynyl, carbocyclyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl portions of Z2a is optionally substituted with 1-4 halogen or C1-C6 alkoxy groups;
• each Z3 is independently oxo, halogen, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)NR17R18, —OR16, —SR16 or —SO2R16;
• wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portions of Z3 is optionally substituted with 1-4 halogen;
• and
• each Z4 is independently oxo, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C5 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)NR17R18, —OR16, —SR16 or —SO2R16, wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portions of Z4 is optionally substituted with 1-4 halogen.