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US 2017/0290826 A1Published application
Cancer treatment method
AssigneeNovartis AG
InventorConnie L. ERICKSON-MILLER
Life of this patent
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Abstract
Invented is a method of treating cancer or a pre-cancerous syndrome in a mammal, including a human, in need thereof which comprises the administration of an effective amount of a non-peptide thrombopoietin (TPO) receptor agonist to such mammal, suitably a human.
Claims8
A method of treating a disease state selected from:
- myelodysplastic syndrome and aplastic anemia, in a mammal in need thereof which comprises the in vivo administration of a therapeutically effective amount of a compound selected from:
- 3′-{N′-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid;
- 3-{N′-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2-hydroxy-3′-tetrazol-5-ylbiphenyl;
- and
- 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridine-2-yl)piperidine-4-carboxylic acid;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.