Small molecule therapies for pulmonary hypertension
AssigneeCreighton University
InventorsYaping Tu, Yan Xie, Peter Abel
Life of this patent
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Abstract
The present disclosure relates to pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) and its derivatives and pharmaceutically acceptable salts thereof, use of these compounds as a medicament, and for the manufacture of a medicament for treating or delaying the onset or development of pulmonary hypertension.
Claims20
A method of treating pulmonary hypertension in a subject, comprising administering to the subject a therapeutically effective amount of a compound of Formula (V):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of H and —(C1-6 alkoxy)-(NR2R3);
- and
- R2 and R3 are each an independently selected C1-6 alkyl group;
- or
- R2 and R3, together with the nitrogen atom to which they are attached, form a monocyclic 4-6 membered heterocycloalkyl ring.
A method of reducing mean pulmonary arterial pressure in a subject, comprising administering to the subject a therapeutically effective amount of a compound of Formula (V):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of H and —(C1-6 alkoxy)-(NR2R3);
- and
- R2 and R3 are each an independently selected C1-6 alkyl group;
- or
- R2 and R3, together with the nitrogen atom to which they are attached, form a monocyclic 4-6 membered heterocycloalkyl ring.
A method of activating endothelial nitric oxide synthase enzyme in a subject, comprising administering to the subject a therapeutically effect amount of a compound of Formula (V):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of H and —(C1-6 alkoxy)-(NR2R3);
- and
- R2 and R3 are each an independently selected C1-6 alkyl group;
- or
- R2 and R3, together with the nitrogen atom to which they are attached, form a monocyclic 4-6 membered heterocycloalkyl ring.
Dependencies are inferred from the claim text.