Oral formulations of deferasirox
AssigneeNovartis AG
InventorsIndrajit Ghosh, Jia-Ai Zhang
Life of this patent
Estimating the term…
Abstract
Orally administerable deferasirox formulations are disclosed having reduced release under gastric conditions and fast release at near neutral pH or at neutral pH.
Claims8
A dosage composition for oral Administration containing deferasirox in an amount selected from the group consisting of 90 mg, 180 mg, and 360 mg, wherein the composition comprises
- (i) at least one filler in a total amount of 10% to 40% by weight based on total weight of the composition;
- (ii) at least one disintegrant in a total amount of 1% to 10% by weight based on the total weight of the composition;
- (iii) at least one binder in a total amount of 1% to 5% by weight based on the total weight of the composition;
- and, optionally, separate from the total weight of the composition;
- and,
- (iv) a coating of the dosage composition.
A dosage composition for oral administration containing deferasirox in an amount selected from the group consisting of 90 mg, 180 mg, and 360 mg, wherein the composition comprises microcrystalline cellulose in an amount of 1% to 55% by weight based on total weight of the dosage composition.
A dosage composition for oral administration containing deferasirox in an amount selected from the group consisting of 90 mg, 180 mg, and 360 mg, wherein the composition comprises
- (i) at least one filler in a total amount of about to 10% to 40% by weight based on the total weight of the composition;
- (ii) at least one disintegrant in a total amount of about 1% to 10% by weight based on the total weight of the composition;
- (iii) at least one binder in a total amount of about 1% to 5% by weight based on the total weight of the composition;
- (iv) at least one surfactant in a total amount of about 0.0% to 2% by weight based on the total weight of the composition;
- and,
- (v) at least one lubricant in a total amount of less than about 0.1% to 2% by weight based on the total weight of the composition.
Dependencies are inferred from the claim text.