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US 2017/0290809 A1Published application
Antiviral agents and uses thereof
AssigneeGriffith University
InventorsMark Von Itzstein, Ibrahim El-Deeb, Larissa Dirr, Patrice Guillon, Moritz Winger
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Abstract
The present invention relates to compounds which are found to exhibit an antiviral effect. The compounds are modulators of the activity of the viral haemagglutinin and/or neuraminidase enzymes.
Claims19
A compound of formula (I), or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is selected from the group consisting of COOH, or a salt thereof, C(O)NR9R10, C(O)OR11 wherein R9, R10 and R11 are independently selected from the group consisting of hydrogen and optionally substituted C1-C6 alkyl;
- R3 is selected from the group consisting of N-linked triazole substituted at one or both ring carbon atoms, optionally substituted N-linked tetrazole, optionally substituted N-linked indole, optionally substituted N-linked isoindole, and optionally substituted N-linked benzotriazole;
- R4 is NHC(O)R17 wherein R17 is selected from the group consisting of C1-C6 alkyl, C1-C6 haloalkyl and C3-C6 cycloalkyl;
- R6, R7 and R8 are independently selected from the group consisting of OH, NH2, C1-C6 alkyl, NR18R18′, C1-C6 alkoxy, —OC(O)R18, —NH(C═O)R18, and S(O)nR18, wherein n=0-2 and each R18 and R18′ are independently hydrogen or optionally substituted C1-C6 alkyl.
2 more elements
Dependencies are inferred from the claim text.