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US 2017/0290803 A1Published application
Parasiticidal compositions comprising indole derivatives, methods and uses thereof
AssigneeMerial Limited
InventorsCharles Meng, Loïc Le Hir de Fallois
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Abstract
The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
Claims20
A compound of formula:
- and salts thereof,
- wherein:
- (A):
- R1 is (C1-C3) alkyl, each independently unsubstituted or substituted with one or more halogens;
- R2 is H, halogen, (C1-C3)-alkyl or (C1-C3)-haloalkyl;
- R3 is phenyl, heteroaryl, phenoxy or heteroaryloxy, wherein the phenyl, heteroaryl, phenoxy or heteroaryloxy may be unsubstituted or substituted with one or more of halogen, (C1-C3)-haloalkyl, (C1-C3)-haloalkoxy or carboxyl;
- R4 is H, halogen, (C1-C3)-alkyl, or (C1-C3)-haloalkyl;
- R5 is H, halogen, (C1-C3)-alkyl, or (C1-C3)-haloalkyl;
- and
- R6 is H, (C1-C3)-alkyl, (C2-C5)-alkenyl, or (C2-C5)-alkynyl, wherein each of (C1-C3)-alkyl, (C2-C5)-alkenyl, or (C2-C5)-alkynyl is independently unsubstituted or substituted with one or more halogens;
- or
- (B):
- R1 is trifluoromethyl;
- R2 is H;
- R3 is 2-dimethylaminomethylphenyl or H;
- R4 is chlorine when R3 is 2-dimethylaminomethylphenyl and R4 is 2-chloro-4-(trifluoromethyl)phenyl when R3 is H;
- and
- R5 and R6 are H.
15 more elements
Dependencies are inferred from the claim text.