Methods of Reducing Blood Lactate Concentration
AssigneeStokely-Van Camp, Inc.
InventorsJeffrey J. ZACHWIEJA, Mark Arthur PIRNER, JohnEric William SMITH
Life of this patent
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Abstract
The present invention is directed to methods for reducing blood lactate concentration during exercise, physical activity or athletic performance.
Claims7
A method of increasing muscle performance in an individual during exercise comprising administering one or more flavanol compounds selected from quercetin, rutin, isoquercetin, isoquercetrin, kaempferol, myricetin, isohamnetin, or sulphate, glucuronide, or glycoside conjugated forms thereof to an individual for a time period prior to exercise;
- engaging in exercise;
- and achieving a lower blood lactate concentration.
A method of identifying a compound effective to reduce lactate concentration in a cell culture media comprising
- subjecting a first set of muscle cells to electrical pulse stimulation,
- measuring lactate concentration in media from the first set of muscle cells,
- contacting a second set of muscle cells with a compound,
- subjecting the second set of muscle cells to electrical pulse stimulation,
- measuring lactate concentration in media from the second set of muscle cells,
- comparing the lactate concentration in the first set of muscle cells with the second set of muscle cells, and
- identifying the compound as effective to reduce lactate concentration when the lactate concentration in the media from the second set of muscle cells is less than the lactic acid concentration in the first set of muscle cells.
(canceled)
A kit for analysis of lactate production resulting from muscle cell contraction comprising differentiated myotubes, one or more of quercetin, rutin, isoquercetin, isoquercetrin, kaempferol, myricetin, or isohamnetin or sulphate, glucoronide or glycoside conjugated forms thereof and one or more test compounds.
A method of increasing power output in an individual during exercise comprising administering one or more flavanol compounds selected from quercetin, rutin, isoquercetin, isoquercetrin, kaempferol, myricetin, isohamnetin, or sulphate, glucuronide, or glycoside conjugated forms thereof to an individual for a time period prior to exercise;
- engaging in exercise;
- and increasing power output to obtain a blood lactate concentration of 4 mmol/L.
A method of increasing % VO2 Peak in an individual during exercise comprising administering one or more flavanol compounds selected from quercetin, rutin, isoquercetin, isoquercetrin, kaempferol, myricetin, isohamnetin, or sulphate, glucuronide, or glycoside conjugated forms thereof to an individual for a time period prior to exercise;
- engaging in exercise;
- and increasing % VO2 Peak to achieve a blood lactate concentration of 4 mmol/L.
Dependencies are inferred from the claim text.