Combination therapies for the treatment of alzheimer's disease and related disorders
AssigneeThe General Hospital Corporation
InventorDavid R. Elmaleh
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Abstract
The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits AB peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with Tau or alpha-synuclein; or regulates amyloid peptide washout.
Claims21
A method of treating a disease or condition in a human subject in need thereof comprising co-administering a therapeutically effective amount of cromolyn or a salt thereof formulated as a powder formulation for inhalation, and a therapeutically effective amount of ibuprofen, wherein the disease or condition is Alzheimer's disease, dementia, an amyloidosis-associated condition, or a head injury.
A method of slowing the progression of a disease or condition in a human subject in need thereof comprising co-administering a therapeutically effective amount cromolyn or a salt thereof formulated as a powder formulation for inhalation, and a therapeutically effective amount of ibuprofen, wherein the disease or condition is Alzheimer's disease, dementia, an amyloidosis-associated condition, or a head injury.
3-20. (canceled)
Dependencies are inferred from the claim text.