Kartogenin-Conjugated Chitosan Particles with Improved Sustained Release Property and Biocombatibility, and Use Thereof
AssigneeDongguk University Industry-Academy Cooperation Foundation
InventorsGun Il Im, Mi Lan Kang
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Abstract
The present invention relates to kartogenin-conjugated chitosan particles with an improved sustained release property and biocompatibility. Effects of increases in biocompatibility, chondrogenic differentiation efficiency and retention time in the joints were confirmed by using kartogenin-chitosan microparticles or kartogenin-chitosan nanoparticles of the present invention, and thus targeted treatment, in the prevention or treatment of bone diseases, is enabled through a more fundamental approach.
Claims8
A kartogenin-conjugated chitosan particle, formed by a covalent bond between kartogenin which is a hydrophobic compound and chitosan which is a hydrophilic compound.
Dependencies are inferred from the claim text.