Use of gabaa receptor reinforcing agent in preparation of sedative and anesthetic medicament

A method for inducing or maintaining general anesthesia or sedation in a mammal, comprising administering to the mammal an effective dose of a compound of general formula (I), or a stereoisomer, a pharmaceutically acceptable salt, or a prodrug thereof, wherein the effective dose is a loading dose and/or a maintenance dose, wherein the loading dose of the compound of general formula (I) is 0.01 mg/kg to 15.0 mg/kg, the maintenance dose of the compound of general formula (I) is 0.01 mg/(kg·h) to 20.0 mg/(kg·h), and the loading dose of the prodrug of the compound of general formula (I) is 0.1 mg/kg to 30.0 mg/kg,

• wherein R1 and R2 are each independently selected from a C1-4 alkyl or a C3-6 cycloalkyl, and wherein n is 1 or 2.

A pharmaceutical composition provided as a liquid formulation or a lyophilized formulation, wherein the liquid formulation or lyophilized formulation comprises a compound of general formula (I), or a stereoisomer, a pharmaceutically acceptable salt, or a prodrug thereof, at a concentration in the liquid formulation or in a solution to be lyophilized into the lyophilized formulation of 0.1 mg/mL to 50.0 mg/mL,

• wherein R1 and R2 are each independently selected from a C1-4 alkyl or a C3-6 cycloalkyl, and wherein n is 1 or 2.

Use of a compound of general formula (I), in combination with one or more additional active ingredients other than the compound of general formula (I), in the manufacture of a medicament for general anesthetization or analgesia in a mammal, wherein the additional active ingredients are selected from drugs having sedative hypnotic activity or anesthetic adjuvant drugs,

• wherein R1 and R2 are each independently selected from a C1-4 alkyl or a C3-6 cycloalkyl, and wherein n is 1 or 2.