Micronized delivery material and methods for manufacturing thereof

A method for manufacturing a drug-delivery composition, comprising:

• mixing at least one anti-caking agent and at least one oil, wherein a fraction of said oil is greater than a final concentration of the ready-for-application delivery mix;
• adding excess of the anti-caking agent to the mixture comprising the anti-caking agent and the oil;
• mixing said anti-caking agent and oil mixture by continuously pressing and folding the mixture to transform the mixture into a microparticulate matrix;
• dissolving at least one pharmaceutically active compound in an aqueous solution;
• adding said pharmaceutically active compound dissolved in the aqueous solution to the microparticulate matrix;
• and
• dispersing the pharmaceutically active compound dissolved in the aqueous solution within the matrix by continuously pressing and folding the matrix.

A method for manufacturing a drug-delivery composition, comprising:

• dissolving at least one pharmaceutically active compound in an aqueous solution;
• mixing said pharmaceutically active compound dissolved in the aqueous solution with at least one anti-caking agent, at least one oil, and water to form a matrix that embeds said pharmaceutically active compound;
• and
• mixing said matrix and said embedded pharmaceutically active compound further until said mixture is transformed into a microparticulate form.