Biodegradable in situ forming microparticles and methods for producing the same
OwnerMichael E. Hudsoninventor
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Abstract
In accordance with the present invention, disclosed herein is a kit comprising a first mixture comprising a pharmaceutically acceptable polar liquid and a fully or nearly fully dissolved biodegradable polymer; a second mixture comprising a pharmaceutically acceptable non-polar liquid; and a mixing device configured to mix the first mixture and second mixture, thereby forming a droplet comprising the biodegradable polymer. Also disclosed herein are methods of producing a microparticle in vivo in a subject.
Claims20
A kit comprising:
- a) a first mixture comprising a pharmaceutically acceptable polar liquid and a fully or nearly fully dissolved biodegradable polymer;
- b) a second mixture comprising a pharmaceutically acceptable non-polar liquid;
- and
- c) a mixing device configured to mix the first mixture and second mixture, thereby forming at least one droplet comprising the biodegradable polymer.
A method of producing a microparticle in vivo in a subject comprising the steps of:
- a) mixing a first mixture comprising a pharmaceutically acceptable polar liquid and a fully or nearly fully dissolved biodegradable polymer in the a pharmaceutically acceptable polar liquid and a second mixture comprising a pharmaceutically acceptable non-polar liquid in a mixing device, thereby forming a droplet comprising the biodegradable polymer;
- and
- b) prior to forming the microparticle, injecting the droplet into a subject with an injection device, thereby forming the microparticle in vivo in the subject.
A method of producing a microparticle in vivo in a subject comprising the steps of:
- a) mixing a biologically active agent with a first solution comprising a pharmaceutically acceptable carrier to form a first composition;
- b) mixing the first composition with a second solution in a first mixing device, wherein the second solution comprises a biodegradable polymer and a pharmaceutically acceptable polar liquid to form a primary emulsion;
- c) mixing the primary emulsion with a second mixture comprising a pharmaceutically acceptable non-polar liquid in a second mixing device to form a droplet within a secondary emulsion;
- and
- d) prior to forming the microparticle, injecting the droplet within the secondary emulsion into a subject with an injection device, thereby forming the microparticle in vivo in the subject.
Dependencies are inferred from the claim text.