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AssigneeTioga Research, Inc.
InventorsEdward Thomas Kisak, John Michael Newsam, Servet Buyuktimkin, Nadir Buyuktimkin
Estimating the term…
Provided herein are topical formulations. The topical formulation may comprise: (i) pregabalin, (ii) water, (iii) DMSO, (iv) a keto acid, and (v) and/or a fatty alcohol. The topical formulation may also comprise (i) pregabalin, (ii) DMSO, (iii) a keto acid and (iv) a fatty acid ester. It has been discovered that the combinations of DMSO with a keto acid such as levulinic acid and/or and a fatty acid ester such as lauryl lactate, or combinations of DMSO with a keto acid such as levulinic acid and/or with a fatty alcohol such as oleyl alcohol are excellent penetration enhancers and, as such, can be incorporated in a skin-applied formulation to facilitate administration of pregabalin.
A topical formulation comprising:
A topical formulation comprising:
A topical formulation comprising:
A topical formulation comprising:
A topical formulation suitable for concentrating a zwitterionic active agent in dermal tissue comprising:
A method for treating a subject suffering from pain, said method comprising the topical administration to said subject of a therapeutically effective amount of formulation comprising:
A method for treating a subject suffering from pain, said method comprising the topical administration to said subject of a therapeutically effective amount of formulation comprising:
Dependencies are inferred from the claim text.