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US 2017/0290765 A1Published application
Injectable formulations for treating cancer
OwnerEdward James Olhava, Angelos Dovletoglou +2inventors
InventorsEdward James Olhava, Angelos Dovletoglou, Steve Wald, Bruce Rehlaender
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Abstract
The present invention provides injectable formulations of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which DOT 1-mediated protein methylation plays a part, such as cancer and neurological disorders.
Claims35
A formulation comprising a compound of Formula (I):
- or an N-oxide, a hydrate, or salt thereof, a solubilizer, and a pH adjustment reagent, wherein the formulation comprises about 1-10% (w/v) compound of Formula (I) and about 4-40% (w/v) solubilizer.
Dependencies are inferred from the claim text.