Neurodegenerative disease screening using an olfactometer

A method, comprising the steps of:

• requesting, by a computing device communicatively coupled to a network delivery of an odor, from among a plurality of odors, from an olfactometer;
• generating, by the computing device, a user interface to be displayed on the computing device;
• receiving, by the computing device via the user interface, a user input for each of an odor memory test, two odor identification tests, and an odor discrimination test;
• calculating, by the computing device, based on a plurality of correct answers queried from a database, a score for the odor memory test and the odor discrimination test;
• calculating, by the computing device, from a relationship between the score for the odor memory test and a plurality of previously-entered performance data queried from the database, a first confidence interval threshold for a first predicted odor memory score;
• calculating, by the computing device, from a relationship between the score for the odor discrimination test and the plurality of previously-entered performance data, a second confidence interval threshold for a second predicted odor memory score;
• determining, by the computing device, whether the score for the odor memory test is greater than the first confidence interval threshold derived from an odor identification test, and the score for the odor memory test is greater than the second confidence interval threshold derived from the odor discrimination test;
• and
• responsive to a determination that the score for the odor memory test is not greater than the first confidence interval threshold and the score for the odor discrimination test is not greater than the second confidence interval threshold, generating, by the computing device, a report, to be displayed by computing device, identifying a user as high risk for a neurodegenerative disease.

A non-transitory computer-readable storage media storing instructions that, when executed by at least one computing device, cause the at least one computing device to:

• request delivery of an odor, from among a plurality of odors, from an olfactometer;
• generate a user interface to be displayed on the at least one computing device;
• receive, via the user interface, a user input for each of an odor memory test and an odor discrimination test;
• calculate, based on a plurality of correct answers queried from a database, a score for the odor memory test and the odor discrimination test;
• calculate, from a relationship between the score for the odor memory test and a plurality of previously-entered performance data queried from the database, a first confidence interval threshold for a first predicted odor memory score;
• calculate, from a relationship between the score for the odor discrimination test and the plurality of previously-entered performance data, a second confidence interval threshold for a second predicted odor memory score;
• determine whether the score for the odor memory test is greater than the first confidence interval threshold and the score for the odor discrimination test is greater than the second confidence interval threshold;
• and
• responsive to a determination that the score for the odor memory test is not greater than the first confidence interval threshold and the score for the odor discrimination test is not greater than the second confidence interval threshold, generate a report, to be displayed by the at least one computing device, identifying a user as high risk for a neurodegenerative disease.