Rodents having a humanized tmprss gene
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsLisa Purcell, Alexander O. Mujica, Yajun Tang
Life of this patent
Estimating the term…
Abstract
Genetically modified rodents such as mice and rats, and methods and compositions for making and using the same, are provided. The rodents comprise a humanization of at least one endogenous rodent Tmprss gene, such as an endogenous rodent Tmprss2, Tmprss4, or Tmprss11d gene.
Claims26
A rodent comprising a humanized Tmprss2 gene that comprises a nucleotide sequence of an endogenous rodent Tmprss2 gene and a nucleotide sequence of a human TMPRSS2 gene, wherein the humanized Tmprss2 gene is under control of the promoter of the endogenous rodent Tmprss2 gene.
A rodent comprising a humanized Tmprss4 gene that comprises a nucleotide sequence of an endogenous rodent Tmprss4 gene and a nucleotide sequence of a human TMPRSS4 gene, wherein the humanized Tmprss4 gene is under control of the promoter of the endogenous rodent Tmprss4 gene.
A rodent comprising a humanized Tmprss11d gene that comprises a nucleotide sequence of an endogenous rodent Tmprss11d gene and a nucleotide sequence of a human TMPRSS11D gene, wherein the humanized Tmprss11d gene is under control of the promoter of the endogenous rodent Tmprss11d gene.
Dependencies are inferred from the claim text.