# US 2017/0286629 A1 · Method for simulating brain stimulation, corresponding device and computer program

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2017/0286629 A1
- Document ID: US20170286629A1
- Status: Published application
- Kind: A1
- Application number: 15/508,161
- Filed: 2015-08-28
- Published: 2017-10-05
- Earliest claimed: 2014-09-04
- Applicants: Universite De Rennes 1; Centre Hospitalier Universitaire De Pontchaillou; Institut National De Sante Et De Recherche Medical
- Inventors: Pierre Jannin; Claire Haegelen; Yulong Zhao
- Web page: https://patentgrep.com/patent/US20170286629A1

## CPC

- G16H 20/70: relating to mental therapies, e.g. psychological therapy or autogenous training
- G16H 20/30: relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
- G16H 20/40: relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
- G16H 50/50: for simulation or modelling of medical disorders
- A61N 1/0534: {Electrodes for deep brain stimulation}
- G16H 40/67: for remote operation
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A method is provided for simulating a brain stimulation, delivering an estimation of a target spatial zone of stimulation. The method includes at least one iteration of the following acts: selection, from among at least two available values, of a value, referred to as a selected value, to be assigned to a pre-determined score; and identification, within an anatomo-clinical atlas belonging to a set of anatomo-clinical atlases, of a spatial zone capable of delivering a value close to said selected value to be assigned to said pre-determined score. The at least one iteration delivers a set of spatial zones. The method further includes a computation, as a function of the set of spatial zones, of at least one target spatial zone, capable of producing a given result representing at least one selected value.

## Claims

### Claim 1

A method for simulating a brain stimulation, delivering an estimation of a target spatial zone of stimulation, wherein the method comprises:
at least one iteration of the following acts performed by a simulation device:
selection, from among at least two available values, of a value, referred to as a selected value, to be assigned to a pre-determined score that corresponds to an expected result; and
identification, within an anatomo-clinical atlas belonging to a set of anatomo-clinical atlases, of a spatial zone capable of delivering a value close to said selected value to be assigned to said pre-determined score;
said at least one iteration delivering a set of spatial zones;
a computation by the simulation device, as a function of said set of spatial zones, of at least one target spatial zone, capable of producing a given result representing the at least one selected value.

### Claim 2 (depends on 1)

The method for simulating according to claim 1, wherein the computation of said target spatial zone comprises an intersection, within a standardized anatomical volume, of said spatial zones of said set of spatial zones.

### Claim 3 (depends on 1)

The method according to claim 1, wherein said set of anatomo-clinical atlases is formed by functional anatomo-clinical atlases of the brain each associating one or more anatomical functions with one or more given spatial zones and comprising, for these given spatial zones, a value representing a progress of a pathology when these spatial zones are stimulated.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the method comprises, prior to said at least one iteration, an act of building said set of anatomo-clinical atlases.

### Claim 5 (depends on 4)

The method according to claim 4, wherein said act of building takes account of at least one characteristic of a patient for whom said method of simulation is implemented.

### Claim 6 (depends on 2)

The method according to claim 2, wherein said target spatial zone is the spatial zone representing the intersection with the highest number of spatial zones of said set of spatial zones.

### Claim 7

A device for simulating a brain stimulation delivering an estimation of a target spatial zone de stimulation, wherein the device comprises:
a non-transitory computer-readable medium comprising instructions stored thereon;
a processor configured by the instructions to perform acts comprising:
selecting, from among at least two available values, of a value, referred to as a selected value, to be assigned to a pre-determined score that corresponds to an expected result;
identifying, within an anatomo-clinical atlas belonging to a set of anatomo-clinical atlases, of a spatial zone capable of delivering a value close to said selected value to be assigned to said pre-determined score;
delivering a set of spatial zones; and
computing, as a function of said set of spatial zones, of at least one target spatial zone, capable of producing a given result representing the selected value.

### Claim 8

A non-transitory computer-readable medium comprising a computer program product stored thereon and executable by a processor of a device for simulating a brain stimulation, wherein the computer program product comprises program code instructions for executing a method for simulating a brain stimulation, when the instructions are executed by the processor, wherein the instructions configure the processor to perform acts comprising:
at least one iteration of the following acts:
selection, from among at least two available values, of a value, referred to as a selected value, to be assigned to a pre-determined score that corresponds to an expected result; and
identification, within an anatomo-clinical atlas belonging to a set of anatomo-clinical atlases, of a spatial zone capable of delivering a value close to said selected value to be assigned to said pre-determined score;
said at least one iteration delivering a set of spatial zones, and
computation, as a function of said set of spatial zones, of at least one target spatial zone, capable of producing a given result representing the at least one selected value.
