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US 2017/0283782 A1Published application
TRPV1 MODULATORY GENE PRODUCT THAT AFFECTS TRPV1-SPECIFIC PAIN BEHAVIORAL RESPONSES IDENTIFIED IN A FUNCTIONAL SCREEN OF AN HSV-BASED cDNA LIBRARY
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsWilliam F. Goins, Joseph C. Glorioso, III, Justus Bernhard Cohen, Bonnie L. Reinhart
Life of this patent
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Abstract
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.
Claims22
A herpes simplex virus (HSV) vector comprising an expression cassette, which expression cassette comprises a nucleic acid sequence encoding PP1α.
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Dependencies are inferred from the claim text.