# US 2017/0282182 A1 · Devices for trapping and controlling microparticles with radiation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2017/0282182 A1 - Document ID: US20170282182A1 - Status: Published application - Kind: A1 - Application number: 15/625,400 - Filed: 2017-06-16 - Published: 2017-10-05 - Earliest claimed: 2015-02-05 - Assignees: International Business Machines Corporation - Applicants: International Business Machines Corporation - Inventors: Jaione Tirapu Azpiroz - Web page: https://patentgrep.com/patent/US20170282182A1 ## CPC - B01L 3/502761: {specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules} - B01L 3/502715: {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces} - B01L 3/50273: {characterised by the means or forces applied to move the fluids} - B03C 5/005: {Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength} - B03C 5/02: Separators - B03C 5/022: {Non-uniform field separators} - G01N 27/44713: {Particularly adapted electric power supply} - G01N 27/44791: {Microapparatus (sample containers with integrated microfluidic structures B01L3/5027)} - B01L 2200/028: Modular arrangements - B01L 2200/0647: Handling flowable solids, e.g. microscopic beads, cells, particles - B01L 2200/143: Quality control, feedback systems - B01L 2300/0627: Sensor or part of a sensor is integrated - B01L 2300/0645: Electrodes - B01L 2300/0816: Cards, e.g. flat sample carriers usually with flow in two horizontal directions - B01L 2300/0864: comprising only one inlet and multiple receiving wells, e.g. for separation, splitting - B01L 2300/0877: Flow chambers - B01L 2400/0424: Dielectrophoretic forces - B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE - B03C: MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS (separating isotopes B01D59/00; combinations of magnetic or electrostatic separation with separation of solids by other means B03B, B07B) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract A particle manipulation device includes a substrate and a microchannel included in the substrate and configured to receive a fluid including particles therein. A biasing structure is formed on the substrate adjacent to, but outside the microchannel. The biasing structure is configured to dispense radiation at a frequency to bias movement of the particles within the microchannel from outside the microchannel. ## Claims ### Claim 1 A particle manipulation device, comprising: a substrate; a microchannel included in the substrate and configured to receive a fluid including particles therein; and at least one biasing structure formed on the substrate outside the microchannel, the at least one biasing structure configured to generate radiation at a frequency to bias movement of the particles within the microchannel from outside the microchannel. ### Claim 2 (depends on 1) The device as recited in claim 1, wherein the microchannel includes at least one chamber for trapping particles biased by the biasing structures. ### Claim 3 (depends on 1) The device as recited in claim 1, wherein the microchannel includes at least one chamber for detecting particles, and the device further comprises an image sensor configured to detect characteristics of the particles in the at least one chamber. ### Claim 4 (depends on 1) The device as recited in claim 1, wherein the microchannel is integrated in the substrate. ### Claim 5 (depends on 1) The device as recited in claim 1, wherein the microchannel is integrated in a removable region that is separable from the substrate. ### Claim 6 (depends on 1) The device as recited in claim 1, wherein the at least one biasing structure is configured to generate non-ionizing radiation. ### Claim 7 A particle manipulation device, comprising: a chip including: at least one biasing structure formed on a substrate, the at least one biasing structure configured to generate radiation at a frequency to bias movement of the particles within a fluid; and a control module including: a generation circuit configured to generate a signal for exciting the biasing structures. ### Claim 8 (depends on 7) The device as recited in claim 7, further comprising a microchannel including one or more of: a plurality of paths configured to separate particles biased by the biasing structures; at least one chamber for trapping particles biased by the biasing structures; or at least one chamber for detecting particles. ### Claim 9 (depends on 7) The device as recited in claim 7, wherein the control module and the chip are integrated on the substrate. ### Claim 10 (depends on 7) The device as recited in claim 7, wherein the control module and the chip are integrated together on a monolithic substrate. ### Claim 11 (depends on 7) The device as recited in claim 7, wherein the chip includes electrical contacts and the control module connects to the electrical contacts as an external device. ### Claim 12 (depends on 7) The device as recited in claim 7, wherein the chip includes a detection structure integrated on the substrate and control module includes a detector interface for providing feedback to adjust the at least one biasing structure. ### Claim 13 (depends on 7) The device as recited in claim 7, wherein the detection structure includes at least one of an antenna or an image sensor configured to detect characteristics of particles in the microchannel. ### Claim 14 (depends on 7) The device as recited in claim 7, wherein the at least one biasing structure is configured to generate non-ionizing radiation to apply dielectrophoresis forces to the particles. ### Claim 15 A method for particle manipulation, comprising: biasing the particles traveling in a fluid using at least one biasing structure formed on a substrate, the at least one biasing structure being configured to generate radiation at a frequency to bias movement of the particles within the fluid. ### Claim 16 (depends on 15) The method as recited in claim 15, further comprising a microchannel including one or more paths and chamber configured to trap, separate or redirect particles biased by the biasing structures. ### Claim 17 (depends on 15) The method as recited in claim 15, further comprising detecting particles using a sensor configured to detect characteristics of the particles. ### Claim 18 (depends on 15) The method as recited in claim 15, wherein the substrate includes a microchannel formed thereon, wherein the microchannel is separable from the substrate, and the method further comprising disposing of the microchannel after use. ### Claim 19 (depends on 15) The method as recited in claim 15, wherein the at least one biasing structure includes at least one antenna, the method further comprising generating radiation to apply dielectrophoresis forces to the particles. ### Claim 20 (depends on 15) The method as recited in claim 15, wherein the at least one biasing structure generates non-ionizing radiation to apply dielectrophoresis forces to the particles.