# US 2017/0281884 A1 · Aerosol Forming Device For Use In Inhalation Therapy

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- Number: US 2017/0281884 A1
- Document ID: US20170281884A1
- Status: Published application
- Kind: A1
- Application number: 15/633,508
- Filed: 2017-06-26
- Published: 2017-10-05
- Earliest claimed: 2001-06-05
- Assignees: Alexza Pharmaceuticals, Inc.
- Applicants: Alexza Pharmaceuticals, Inc.
- Inventors: Craig C. Hodges; Peter M. Lloyd; Daniel Mufson; Daniel D. Rogers; Martin J. Wensley
- Web page: https://patentgrep.com/patent/US20170281884A1

## CPC

- A61M 11/044: {with electrodes immersed in the liquid}
- A61K 9/007: {Pulmonary tract; Aromatherapy}
- A61K 9/0073: {Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; (nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M)}
- A61K 31/235: having an aromatic ring attached to a carboxyl group
- A61K 31/4468: having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
- A61K 31/485: Morphinan derivatives, e.g. morphine, codeine
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61M 11/001: {Particle size control}
- A61M 11/02: operated by air {or other gas} pressure applied to the liquid {or other product} to be sprayed or atomised {(sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C)}
- A61M 15/00: Inhalators {(drug delivery in endotracheal tubes A61M16/04)}
- A61M 15/0028: {using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up}
- A61M 16/109: {the humidifying liquid or the beneficial agent}
- A61P 23/00: Anaesthetics
- B05B 7/1686: {involving vaporisation of the material to be sprayed or of an atomising-fluid-generating product}
- B05B 17/04: operating with special methods
- A61M 2016/0039: {in the inspiratory circuit}
- A61M 2205/3606: cooled
- A61M 2205/3653: by Joule effect, i.e. electric resistance
- A61M 2205/368: by electromagnetic radiation, e.g. IR waves
- A61M 2205/50: with microprocessors or computers
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- B05B: SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES (spray-mixers with nozzles B01F25/72; processes for applying liquids or other fluent materials to surfaces by spraying B05D)

## Abstract

The present disclosure relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a device that forms drug containing aerosols for use in inhalation therapy. In a device aspect of the present disclosure, a device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.

## Claims

### Claim 1

A device for delivering apomorphine containing aerosols including: a housing; and, an airway including a gas/vapor mixing area, wherein the airway includes a subassembly, and wherein the subassembly includes a metallic substrate, and wherein a composition comprising apomorphine is coated on the substrate.

### Claim 2

A device for delivering fentanyl containing aerosols including: a housing; and, an airway including a gas/vapor mixing area, wherein the airway includes a subassembly, and wherein the subassembly includes a metallic substrate, and wherein a composition comprising fentanyl is coated on the substrate.