# US 2017/0281735 A1 · Compositions and Methods for the Treatment of Photoaging and Other Conditions

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- Number: US 2017/0281735 A1
- Document ID: US20170281735A1
- Status: Published application
- Kind: A1
- Application number: 15/506,821
- Filed: 2015-08-20
- Published: 2017-10-05
- Earliest claimed: 2014-08-25
- Assignees: ProTransit Nanotherapy, LLC
- Applicants: Pro Transit Nanotherapy LLC
- Inventors: Vinod D. Labhasetwar
- Web page: https://patentgrep.com/patent/US20170281735A1

## CPC

- A61K 38/446: {Superoxide dismutase (1.15)}
- A61K 8/0241: {Containing particulates characterized by their shape and/or structure (see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes)}
- A61K 8/29: Titanium; Compounds thereof
- A61K 8/66: Enzymes
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 9/5123: {Organic compounds, e.g. fats, sugars}
- A61K 9/5138: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates}
- A61K 9/5153: {Polyesters, e.g. poly(lactide-co-glycolide)}
- A61K 38/44: Oxidoreductases (1)
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61Q 19/08: Anti-ageing preparations
- C12Y 111/01006: Catalase (1.11.1.6)
- C12Y 115/01001: Superoxide dismutase (1.15.1.1)
- A61K 2800/522: Antioxidants; Radical scavengers
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C12Y: ENZYMES

## Abstract

Compositions and methods for the treatment of skin disorders or disease are provided.

## Claims

### Claim 1

A method of treating, inhibiting, and/or preventing a skin disease or disorder in a subject in need thereof, said method comprising topically administering at least one nanoparticle to the skin of the subject,
wherein said nanoparticle comprises at least one biodegradable polymer and at least one antioxidant enzyme.

### Claim 2 (depends on 1)

The method of claim 1, wherein said antioxidant enzyme is catalase or superoxide dismutase.

### Claim 3 (depends on 1)

The method of claim 1, wherein said skin disease or disorder is ultraviolet radiation-induced.

### Claim 4 (depends on 1)

The method of claim 1, wherein said skin disease or disorder is photoaging, skin cancer, or sunburn.

### Claim 5 (depends on 1)

The method of claim 1, further comprising administering at least one other antioxidant.

### Claim 6 (depends on 1)

The method of claim 1, further comprising administering at least one metal oxide nanoparticle.

### Claim 7 (depends on 1)

The method of claim 1, wherein said biodegradable polymer is poly (lactide-co-glycolide).

### Claim 8 (depends on 1)

The method of claim 1, wherein said nanoparticle further comprises at least one plasticizer.

### Claim 9 (depends on 8)

The method of claim 8, wherein said plasticizer is dimethyl tartrate.

### Claim 10 (depends on 1)

The method of claim 1, wherein said nanoparticle further comprises at least one emulsifier.

### Claim 11 (depends on 10)

The method of claim 10, wherein said emulsifier is polyvinyl alcohol.

### Claim 12 (depends on 1)

The method of claim 1, wherein said method comprises administering 1) nanoparticles comprising at least one biodegradable polymer and catalase, and 2) nanoparticles comprising at least one biodegradable polymer and superoxide dismutase.

### Claim 13 (depends on 12)

The method of claim 12, wherein the ratio of superoxide nanoparticles to catalase nanoparticles is about 1:5 to about 1:1.

### Claim 14 (depends on 1)

The method of claim 1, wherein said nanoparticles are formulated by an emulsion solvent evaporation method.

### Claim 15 (depends on 12)

The method of claim 12, wherein said biodegradable polymer is poly (lactide-co-glycolide).

### Claim 16 (depends on 15)

The method of claim 15, wherein said nanoparticles further comprise at least one plasticizer.

### Claim 17 (depends on 16)

The method of claim 16, wherein said plasticizer is dimethyl tartrate.

### Claim 18

A topical composition comprising 1) a carrier acceptable for topical delivery, 2) nanoparticles comprising at least one biodegradable polymer and catalase, and 3) nanoparticles comprising at least one biodegradable polymer and superoxide dismutase.

### Claim 19 (depends on 18)

The composition of claim 18, wherein said biodegradable polymer is poly (lactide-co-glycolide).