# US 2017/0281689 A1 · Fish oil topical composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2017/0281689 A1 - Document ID: US20170281689A1 - Status: Published application - Kind: A1 - Application number: 15/478,889 - Filed: 2017-04-04 - Published: 2017-10-05 - Earliest claimed: 2016-04-04 - Assignees: Omeza LLC - Applicants: Omeza LLC - Inventors: Griscom BETTLE, III - Web page: https://patentgrep.com/patent/US20170281689A1 ## CPC - A61K 35/60: Fish, e.g. seahorses; Fish eggs - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} - A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) - A61K 36/889: Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto - A61K 38/39: Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG] - A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters - A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14) - A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract Disclosed is a method of reducing the rancid fish odor smell in a topical composition comprised of fish oil which comprises mixing the composition with monolaurin. Also disclosed are various anhydrous topical compositions comprising fish oil. One comprises fish oil, cetyl ester, palm olein, medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids, mixture of C8/C10 fatty acids, and monolaurin, another one comprises fish oil, cetyl ester, palm olein, medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids, mixture of C8/C10 fatty acids, monolaurin, collagen and sea salt, an a third one comprises fish oil, cetyl ester, palm olein, medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids, mixture of C8/C10 fatty acids, monolaurin and hydrocolloid. These compositions are useful for treating wounds and skin conditions. ## Claims ### Claim 1 An anhydrous topical composition comprising fish oil in an amount ranging from about 40% to about 60% by weight, palm olein present in an amount ranging from about 10% to about 20% by weight, C8/C10 fatty acid in an amount ranging from about 0.5% to about 4% by weight, C8/C10 triglyceride present in an amount ranging from about 25% to 35% by weight, cetyl ester ranging from about 0.5% to about 2% by weight and monolaurin ranging from about 0.5% to about 2% by weight, wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and C8/10 triglyceride to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and C8/C10 ranges from about 1.8 to about 2.2, wherein the sum of the dry weight percent of all of the components present is equal to 100%. ### Claim 2 (depends on 1) The anhydrous topical composition according to claim 1 wherein the fish oil is salmon oil. ### Claim 3 (depends on 1) The anhydrous topical composition according to claim 1 wherein the palm olein is red palm olein or red palm super olein. ### Claim 4 (depends on 1) The anhydrous topical composition according to claim 1 wherein the composition is a spray, an oil-impregnated wipe, a liquid or a gel. ### Claim 5 (depends on 1) The anhydrous topical composition according to claim 1 which comprises about 48% salmon oil by weight, about 16% red palm super olein by weight, about 1.0% cetyl ester by weight, about 0.6% monolaurin by weight, C8/C10 fatty acid in about 2% by weight, and a C8/C10 triglyceride in about 32% by weight. ### Claim 6 An anhydrous topical composition comprising fish oil present in an amount ranging from about 20% to about 40% by weight, palm olein present in an amount ranging from about 6% to about 10% by weight, C8/C10 triglyceride present in an amount ranging from about 14% to 18% by weight, cetyl ester ranging from about 0.3% to about 1% by weight; monolaurin ranging in an amount from about 3% % to about 6% by weight; collagen having a glass transition temperature less than 37° C. ranging in an amount from about 35% to about 55% by weight and sea salt ranging in an amount from about 0.3 to about 0.9% by weight, wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and C8/C10 triglyceride to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and C8/C10 triglyceride ranges from about 1.8 to about 2.2, wherein the sum of the dry weight percent of all of the components present is equal to 100%. ### Claim 7 (depends on 6) The anhydrous topical composition according to claim 6 wherein the fish oil is salmon oil. ### Claim 8 (depends on 6) The anhydrous topical composition according to claim 6 wherein the collagen is fish collagen. ### Claim 9 (depends on 6) The anhydrous topical composition according to claim 6 wherein the palm olein is red palm olein. ### Claim 10 (depends on 6) The anhydrous topical composition according to claim 6 in the form of a gel, a paste or a gel impregnated wipe. ### Claim 11 (depends on 6) The anhydrous topical composition according to claim 6 comprising salmon oil being present in about 24.9% by weight, palm olein being present in about 8.3% by weight, C8/C10 fatty acids being present in about 1.0% by weight, C8/C10 triglyceride being present in about 16.6% by weight, cetyl ester being present in about 0.51% by weight; monolaurin being present in about 4.0% by weight; fish collagen being present in about 44.0%, and sea saline being present in about 0.6% by weight. ### Claim 12 (depends on 1) A method of treating a wound or skin condition on a subject which comprises applying on the wound or skin condition an effective amount of an anhydrous topical composition according to claim 1. ### Claim 13 (depends on 6) A method of treating a wound or skin condition on a subject which comprises applying on the wound or skin condition an effective amount of an anhydrous topical composition according to claim 6. ### Claim 14 (depends on 1) The composition according to claim 1 wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and C8/C10 triglyceride to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and C8/C10 triglyceride ranges from about 1.9 to about 2.1 ### Claim 15 (depends on 1) The composition according to claim 1 wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and C8/C10 triglyceride to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and C8/C10 triglyceride ranges from about1.95 to about 2.05. ### Claim 16 (depends on 1) The composition according to claim 1 wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and C8/C10 triglyceride to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and C8/C10 triglyceride is about 2. ### Claim 17 (depends on 1) The composition according to claim 1 which comprises fish oil, containing omega-3 fatty acid present in an amount ranging from about 45% to about 52% by weight, palm olein present in an amount ranging from about 14% to about 18% by weight, a mixture of free fatty acids of C8 to C10 in a weight ratio of C8 to C10 fatty acid of 1.3 to 1.6, said mixture present in an amount ranging from 1% to about 3% by weight, medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids present in an amount ranging from about 28% to 34% by weight, cetyl ester ranging from about 1.0% to about 2% by weight and monolaurin, ranging from about 0.5% to about 1.5% by weight, wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids ranges from about 1.8 to about 2.2, wherein the sum of the dry weight % of all of the components present in the composition is 100%. ### Claim 18 (depends on 1) The composition according to claim 1 wherein the weight ratio of fish oil to cetyl ester ranges from about 40:1 to about 60:1. ### Claim 19 (depends on 1) The composition according to claim 1 wherein the weight ratio of C8/C10 fatty acid to cetyl ester is about 2:1. ### Claim 20 (depends on 1) The composition according to claim 1 wherein the weight ratio of fish oil to palm olein ranges from ranges from about 6:1 to about 1.5:1. ### Claim 21 (depends on 8) The composition according to claim 8 wherein the weight ratio of C8/C10 triglyceride to C8/C10 fatty acids ranges from about 10:1 to about 25:1. ### Claim 22 (depends on 1) The composition according to claim 1 wherein the weight ratio of C8/C10 triglyceride to palm olein ranges from about 1.3:1 to about 4:1. ### Claim 23 (depends on 1) The composition according to claim 1 wherein the weight ratio of cetyl ester to monolaurin per gram of fish oil ranges from about 1.1 to about 3:1. ### Claim 24 (depends on 6) The composition according to claim 6 wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and C8/C10 triglyceride to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and C8/C10 triglyceride ranges from about1.9 to about 2.1 ### Claim 25 (depends on 6) The composition according to claim 6 wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and C8/C10 triglyceride of C8 to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and C8/C10 triglyceride ranges from about1.95 to about 2.05. ### Claim 26 (depends on 6) The composition according to claim 6 wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids is about 2. ### Claim 27 (depends on 6) The composition according to claim 6 which comprises fish oil present in an amount ranging from about 20% to about 30% by weight, palm olein present in about ranging from about 7% to about 9% by weight, a medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids present in an amount ranging from about 15% to about 18% by weight, a mixture of C8 and C10 free fatty acids present in an amount ranging from about 0.5% to about 1.5% by weight, cetyl ester ranging from about 0.3% to about 0.7% by weight; monolaurin, ranging from about 3% to about 5% by weight; said collagen ranging from about 40% to about 50% by weight and sea salt ranging from about 0.4 to about 0.7 by weight, wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids ranges from about 1.8 to about 2.2, wherein the sum of the dry weight % of all of the components present in the composition is 100%. ### Claim 28 (depends on 6) The composition according to claim 6 which comprises fish oil present in an amount ranging from about 22% to about 26% by weight, palm olein present in about ranging from about 8% to about 9% by weight, a medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids present in an amount ranging from about 16% to about 17% by weight, a mixture of C8 and C10 free fatty acids present in an amount ranging from about 0.8% to about 1.2% by weight, cetyl ester present in an amount ranging from about 0.4% to about 0.6% by weight; monolaurin, present in an amount ranging from about 3.5% to about 4.5% by weight; fish collagen present in an amount ranging from about 43% to about 46% by weight and sea saline is present in an amount ranging from about 0.5% to about 0.6% by weight, wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids ranges from about 1.8 to about 2.2, wherein the sum of the dry weight % of all of the components present in the composition is 100%. ### Claim 29 (depends on 6) The composition according to claim 6 wherein the fish oil is present in an amount ranging from about 24% to about 25% by weight, palm olein is present in about ranging from about 8.2% to about 8.5% by weight, a medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids is present in an amount ranging from about 16.5% to about 16.8% by weight, a mixture of C8 and C10 free fatty acids is present in an amount ranging from about to about 1.1% by weight, cetyl ester is present in an amount ranging from about 0.5% to about 0.55% by weight; monolaurin, is present in an amount ranging from about 3.8% to about 4.2% by weight; collagen is present in an amount ranging from about 43.5% to about 44.5% by weight and sea salt is present in an amount ranging from about 0.52% to about 0.62% by weight, wherein the weight ratio of the sum of the saturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids to the sum of the mono-unsaturated compounds in the salmon oil, palm olein and triglyceride mixture of C8 and C10 fatty acids ranges from about 1.8 to about 2.2, wherein the sum of the dry weight % of all of the components present in the composition is 100%. ### Claim 30 (depends on 6) The composition according to claim 6 wherein the weight ratio of fish oil to cetyl ester ranges from about 40:1 to about 60:1. ### Claim 31 (depends on 6) The composition according to claim 6 wherein the weight ratio of C8/C10 fatty acid to cetyl ester is about 2:1. ### Claim 32 (depends on 6) The composition according to claim 6 wherein the weight ratio of fish oil to palm olein ranges from ranges from about 6:1 to about 1.5:1. ### Claim 33 (depends on 6) The composition according to claim 6 wherein the weight ratio C8/C10 triglyceride to C8/C10 fatty acids ranges from about 10:1 to about 25:1. ### Claim 34 (depends on 6) The composition according to claim 6 wherein the weight ratio of C8/C10 triglyceride to palm olein ranges from about 1.3:1 to about 4:1. ### Claim 35 (depends on 6) The composition according to claim 6 wherein the weight ratio of monolaurin to cetyl ester per gram of fish oil ranges from about 3:1 to about 9:1. ### Claim 36 (depends on 12) The method according to claim 12 wherein the fish oil is salmon oil. ### Claim 37 (depends on 13) The method according to claim 13 wherein the fish oil is salmon oil. ### Claim 38 (depends on 1) A method of treating the lower leg skin after vascular surgery for peripheral arterial disease comprising topically applying to the lower leg skin an effective amount of a composition according to claim 1. ### Claim 39 (depends on 6) A method of treating the lower leg skin after vascular surgery for peripheral arterial disease comprising topically applying to the lower leg skin an effective amount of a composition according to claim 6. ### Claim 40 A method for removing the rancid fish smell from a topical fish oil composition win which collagen is absent therefrom comprising adding monolaurin to and mixing with the fish oil composition in a weight ratio of fish oil to monolaurin ranging from about 100 to about 1 to about 25 to 1. ### Claim 41 (depends on 40) The method according to claim 40 wherein the fish oil is present n an amount ranging from about 30% to about 70% by weight. ### Claim 42 (depends on 40) The method according to claim 40 wherein cetyl ester is additionally added and mixed with the monolaurin and the fish oil composition. ### Claim 43 (depends on 42) The method according to claim 42 wherein the weight ratio of cetyl ester to monolaurin per gram of fish oil ranges from about 2:1 to about 0.12:1. ### Claim 44 An anhydrous topical composition comprised of fish oil in an amount ranging from about 30% by weight to about 70% by weight, monolaurin present in an amount ranging from about 0.5% to about 2% by weight, cetyl ester present in an amount ranging from about 0.5% to about 2% by weight. ### Claim 45 (depends on 44) The anhydrous topical composition of claim 44, wherein the weight ratio of cetyl ester to monolaurin ranges from about 5:1 to about 1:1. ### Claim 46 (depends on 44) The anhydrous topical composition according to claim 44 wherein the cetyl ester is present in a greater amount by weight than monolaurin. ### Claim 47 (depends on 44) A method of treating a wound or skin condition on a subject which comprises applying on the wound or skin condition an effective amount of an anhydrous topical composition according to claim 44. ### Claim 48 (depends on 38) The method according to claim 38 wherein the fish oil is salmon oil. ### Claim 49 (depends on 39) The method according to claim 39 wherein the fish oil is salmon oil. ### Claim 50 (depends on 40) The method according to claim 40 wherein the fish oil is salmon oil.